인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 저자정보
피인용 0
초록·키워드
Microfluidic systems with the ability to mimic the female reproductive tract (FRT) and sperm features have emerged aspromising methods to separate sperm with higher quality for the assistant reproductive technology. Thereby, we designed andfabricated a microfluidic system based on FRT features with a focus on rheotaxis and thigmotaxis for passive sperm separation.
In this regard, four various geometries (linear, square, zigzag, and sinusoidal) were designed, and the effect of rheotaxisand thigmotaxis were investigated. Although separated sperm in all microchannels were 100% motile, non-linear geometrieswere more effective than linear geometry in the term of separating the progressive sperm with high quality. In the presenceof upstream flow, periodical changes in the slope of walls (in non-linear geometries) give rise to the periodical facing spermwith a high flow rate in the middle of microchannels, which was a reason for the high quality of separated sperm. However,because of sharp corners in the square and zigzag microchannels that create dead zones with a lack of upstream flow, whichis noticeable via simulation results, these geometries have obstacles against sperm swimming toward the outlet, whichwas proved by image analysis. The sinusoidal geometry showed the highest enhancement level of the designed geometriescompared to the linear geometry. Separated sperm exhibited 34.7% normal morphology, 100% motility, and 100% viabilityin the sinusoidal geometry. Therefore, the periodic change in the position of sperm from one wall to another wall can be astrategy for separating sperm with high quality.
본문·목차
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