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저자정보
(경북대학교) (경북대학교) (경북대학교)
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한국식품영양과학회 한국식품영양과학회지 한국식품영양과학회지 제53권 제5호
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    초록·키워드

    In this study, we aimed to extract valuable components from Aeonium sedifolium. Extraction using 50% ethanol yielded higher levels of total phenolic compound and resulted in higher inhibition of hyaluronidase compared to water extraction. Cytotoxicity assays on Raw 264.7 cells revealed no adverse effects at concentrations below 50 and 20 μg/mL in water and ethanol extracts, respectively. Furthermore, the exhibited concentration-dependent inhibition of nitric oxide production, with microwave extraction (ME) demonstrating superior inhibition compared to conventional extraction (CE). Protein expression levels of cyclooxygenase 2 and inducible nitric oxide synthase were also suppressed in both ME and CE extracts, with ME showing greater efficacy than CE. Additionally, inflammatory cytokines including tumor necrosis factor-α, interleukin (IL)-1β, IL-6, monocyte chemoattractant protein-1, and prostaglandin E synthase 2 were suppressed, with ME exhibiting higher inhibition rates. These findings highlight the anti-inflammatory activity of A. sedifolium extracts, with ME proving to be more effective than conventional methods.

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      UCI(KEPA) : I410-151-24-02-089814366