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논문 기본 정보

자료유형
학술저널
저자정보
Hyunwoo Lim (Kyung Hee University) Yeek Herr (Kyung Hee University Medical Center) Jong-Hyuk Chung (Kyung Hee University Medical Center) Seung-Yun Shin (Kyung Hee University Medical Center) Seung-Il Shin (Kyung Hee University Medical Center) Ji-Youn Hong (Kyung Hee University Medical Center) Hyun-Chang Lim (Kyung Hee University Medical Center)
저널정보
대한치의학회 Journal of Korean Dental Science Journal of korean dental science Vol.17 No.2
발행연도
2024.6
수록면
53 - 63 (11page)

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초록· 키워드

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Purpose: To investigate the effects of simultaneous soft and hard tissue augmentation and the addition of polydeoxyribonucleotide (PDRN) on regenerative outcomes. Materials and Methods: In five mongrel dogs, chronic ridge defects were established in both mandibles. Six implants were placed in the mandible, producing buccal dehiscence defects. The implants were randomly allocated to one of the following groups: 1) control: no treatment; 2) GBR: guided bone regeneration (GBR) only; 3) GBR/PDRN: GBR+PDRN application to bone substitute particles; 4) GBR/CTG: GBR+connective tissue grafting (CTG); 5) GBR/VCMX: GBR+soft tissue augmentation using volume stable collagen matrix (VCMX); and 6) group GBR/VCMX/PDRN: GBR+VCMX soaked with PDRN. The healing abutments were connected to the implants to provide additional room for tissue regeneration. Submerged healing was achieved. The animals were euthanized after four months. Histological and histomorphometric analyses were then performed. Results: Healing abutments were gradually exposed during the healing period. Histologically, minimal new bone formation was observed in the dehiscence defects. No specific differences were found between the groups regarding collagen fiber orientation and density in the augmented area. No traces of CTG or VCMX were detected. Histomorphometrically, the mean tissue thickness was greater in the control group than in the other groups above the implant shoulder (IS). Below the IS level, the CTG and PDRN groups exhibited more favorable tissue thickness than the other groups. Conclusion: Failure of submerged healing after tissue augmentation deteriorated the tissue contour. PDRN appears to have a positive effect on soft tissues.

목차

Introduction
Materials and Methods
Results
Discussion
Conclusion
References

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