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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.6
- 수록면
- 143 - 154 (12page)
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초록· 키워드
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Immunomodulators, including recombinant proteins, immunoglobulins, and cell therapeutics, can activate or suppress the human immune system. Mesenchymal stem cells have immunoregulatory functions and could be used as cell therapeutics. In this study, we hypothesized that exogenous MSCs would regulate the immune response by influencing the recruitment of T lymphocytes in peripheral tissues. In a mouse allogeneic bone marrow transplantation model, bone marrow with MSCs from C57BL/6 mice (H-2<SUP>b</SUP>) was transferred to BALB/c mice (H-2<SUP>d</SUP>) pre-conditioned with busulfan-cyclophosphamide. The proportion of CD3<SUP>+</SUP> cells in the spleen was lower in the MSC co-transplantation group. When MSCs were administered, the expression of CD69 decreased in the spleen, while CD62L increased in the blood. In vitro, T-MSC co-cultured splenic T cells showed decreased expression of CCRL2, ACKR2, IFNG, TLR4, CXCR2, CCL5, CCR5, IL4, and CCL20 and increased expression of CXCL9, ACTB, CXCR6, CCR9, CCR4, CCL28, and MAPK1. This study provides a clue to the immune modulatory effect of MSCs by regulating lymphocyte migration in the peripheral lymphoid tissues by secreting chemokines, inducing chemokine receptor expression, or CD69-mediated regulation.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
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