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논문 기본 정보

자료유형
학술저널
저자정보
Kim Min-Gul (Center for Clinical Pharmacology, Jeonbuk National University Hospital, Jeonju 54907, KoreaResearch Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institut) Kim Suin (College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Korea) Jeon Ji-Young (Center for Clinical Pharmacology, Jeonbuk National University Hospital, Jeonju 54907, Korea) Moon Seol Ju (Center for Clinical Pharmacology, Jeonbuk National University Hospital, Jeonju 54907, KoreaResearch Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institut) Kwak Yong-Geun (Center for Clinical Pharmacology, Jeonbuk National University Hospital, Jeonju 54907, KoreaDepartment of Pharmacology, School of Medicine, Jeonbuk National University, Jeonju 54907, Korea) Na Joo Young (Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul 03080, Korea) Lee SeungHwan (Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul 03080, Korea) Park Kyung-Mi (Genome and Company, Seoungnam 13486, Korea) Kim Hyo-Jin (Genome and Company, Seoungnam 13486, Korea) Lee Sang-Min (College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Korea) Choi Seo-Yeon (College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Korea) Shin Kwang-Hee (College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Korea)
저널정보
대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제28권 제2호
발행연도
2024.3
수록면
153 - 164 (12page)
DOI
10.4196/kjpp.2024.28.2.153

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초록· 키워드

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This study aimed to identify metabolic biomarkers and investigate changes in intestinal microbiota in the feces of healthy participants following administration of Lactococcus lactis GEN-001. GEN-001 is a single-strain L. lactis strain isolated from the gut of a healthy human volunteer. The study was conducted as a parallel, randomized, phase 1, open design trial. Twenty healthy Korean males were divided into five groups according to the GEN-001 dosage and dietary control. Groups A, B, C, and D1 received 1, 3, 6, and 9 GEN-001 capsules (1 × 1011 colony forming units), respectively, without dietary adjustment, whereas group D2 received 9 GEN-001 capsules with dietary adjustment. All groups received a single dose. Fecal samples were collected 2 days before GEN-001 administration to 7 days after for untargeted metabolomics and gut microbial metagenomic analyses; blood samples were collected simultaneously for immunogenicity analysis. Levels of phenylalanine, tyrosine, cholic acid, deoxycholic acid, and tryptophan were significantly increased at 5–6 days after GEN-001 administration when compared with predose levels. Compared with predose, the relative abundance (%) of Parabacteroides and Alistipes significantly decreased, whereas that of Lactobacillus and Lactococcus increased; Lactobacillus and tryptophan levels were negatively correlated. A single administration of GEN-001 shifted the gut microbiota in healthy volunteers to a more balanced state as evidenced by an increased abundance of beneficial bacteria, including Lactobacillus, and higher levels of the metabolites that have immunogenic properties.

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