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논문 기본 정보

자료유형
학술저널
저자정보
박소희 (Department of Dermatology, Haeundae Paik Hospital, College of Medicine, Inje University, Busan, Korea.) 김효진 (Department of Dermatology, Busan Paik Hospital, College of Medicine, Inje University, Busan, Korea.) 김종욱 (Department of Dermatology, Busan Paik Hospital, College of Medicine, Inje University, Busan, Korea.) 홍승민 (Department of Dermatology, Busan Paik Hospital, College of Medicine, Inje University, Busan, Korea.) 안상우 (Department of Dermatology, Busan Paik Hospital, College of Medicine, Inje University, Busan, Korea.)
저널정보
대한피부과학회 Annals of Dermatology Annals of Dermatology Vol.36 No.1
발행연도
2024.2
수록면
29 - 34 (6page)
DOI
10.5021/ad.23.026

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Background: Analysis of hair microscopic morphology is a simple and less invasive method to differentiate alopecia areata (AA) from other alopecic diseases. However, there is limited information on the distribution of the microscopic characteristics. Objective: This study evaluated the microscopic morphological characteristics of pulled-out hair and their correlation with disease course in AA. Methods: Morphological characteristics of pulled-out hair were classified into 5 categories: the presence of typical clubbing, surface undulation, tapering, breakage, and depigmentation in proximal hair shaft. Clinical course of AA was investigated through assessment of Severity of Alopecia Tool (SALT) score (initial score, maximal score and difference of them [ΔSALT]). Results: Among 1,272 pulled-out hairs (n=179) obtained at initial visit, depigmentation (59.5%) was the most common, followed by loss of typical clubbing (57.2%) and surface undulation (55.2%). The percentage of loss of typical clubbing and proximal tapering was significantly higher in severe type of AA, younger age of onset and shorter disease duration. The ratio of typical clubbing (<50% vs. ≥50%) was associated with difference in maximal score and ΔSALT (p<0.05). Strong activity group (pulled-out hair ≥10, n=33) showed difference in clinical course (maximal score, ΔSALT) as well as distribution of microscopic features (loss of typical clubbing) compared with those in non-strong activity group. The ratio of typical clubbing significantly increased at follow-up than initially in strong activity group (p<0.05). Conclusion: Microscopic hair morphology, especially loss of typical clubbing and proximal tapering, could be useful tool to predict the course of AA.

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