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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology Vol.17 No.1
- 발행연도
- 2024.2
- 수록면
- 1 - 14 (14page)
- DOI
- https://doi.org/10.21053/ceo.2023.01382
이용수
초록· 키워드
오류제보하기
Cochlear hair cells convert sound into electrical signals that are relayed via the spiral ganglion neurons to the central audi-tory pathway. Hair cells are vulnerable to damage caused by excessive noise, aging, and ototoxic agents. Non-mammals canregenerate lost hair cells by mitotic regeneration and direct transdifferentiation of surrounding supporting cells. However,in mature mammals, damaged hair cells are not replaced, resulting in permanent hearing loss. Recent studies have uncov-ered mechanisms by which sensory organs in non-mammals and the neonatal mammalian cochlea regenerate hair cells,and outlined possible mechanisms why this ability declines rapidly with age in mammals. Here, we review similarities anddifferences between avian, zebrafish, and mammalian hair cell regeneration. Moreover, we discuss advances and limitationsof hair cell regeneration in the mature cochlea and their potential applications to human hearing loss.
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