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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 소화기인터벤션의학회 International Journal of Gastrointestinal Intervention International Journal of Gastrointestinal Intervention Vol.13 No.1
- 발행연도
- 2024.1
- 수록면
- 11 - 15 (5page)
- DOI
- 10.18528/ijgii240002
이용수
초록· 키워드
오류제보하기
Background: Anastomotic leak (AL) is one of the most feared complications following intestinal surgery and is associated with increased complications, costs, length of hospital stay, and mortality. While many pre-clinical animal model studies have successfully demonstrated the efficacy of amniotic membrane (AM) in preventing AL, its clinical utility is less reported.
Methods: A single-center, retrospective study was performed on patients who underwent intestinal surgery followed by end-to-end or side-by-side single layer anastomosis and placement of cryopreserved, ultra-thick AM. Post-operative outcomes were assessed including time to first defecation, length of hospital stay, and complications, including incidence of AL.
Results: Eleven consecutive patients (7 male, 4 female) underwent open (n = 2) or laparoscopic (n = 9) resection of the sigmoid (n = 6), cecum (n = 2), ascending colon (n = 1), rectum (n = 1), and small bowel (n = 1). Surgery was uneventful in all cases. The time to first defecation was 3.5 ± 2.1 days.
After an average follow up of 65.3 ± 42.0 days, none of the patients suffered an AL nor required another colorectal procedure.
Conclusion: These preliminary findings suggest the use of cryopreserved, ultra-thick AM following intestinal surgery is safe and may be beneficial in reducing the incidence of AL and post-operative complications. Larger prospective, randomized trials are warranted.
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