지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.4
- 수록면
- 47 - 65 (19page)
이용수
초록· 키워드
오류제보하기
Viral load and the duration of viral shedding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are important determinants of the transmission of coronavirus disease 2019. In this study, we examined the effects of viral doses on the lung and spleen of K18-hACE2 transgenic mice by temporal histological and transcriptional analyses. Approximately, 1×10<sup>5</sup> plaque-forming units (PFU) of SARS-CoV-2 induced strong host responses in the lungs from 2 days post inoculation (dpi) which did not recover until the mice died, whereas responses to the virus were obvious at 5 days, recovering to the basal state by 14 dpi at 1×10² PFU. Further, flow cytometry showed that number of CD8+ T cells continuously increased in 1×10² PFU-virusinfected lungs from 2 dpi, but not in 1×10<sup>5</sup> PFU-virus-infected lungs. In spleens, responses to the virus were prominent from 2 dpi, and number of B cells was significantly decreased at 1×10<sup>5</sup> PFU; however, 1×10² PFU of virus induced very weak responses from 2 dpi which recovered by 10 dpi. Although the defense responses returned to normal and the mice survived, lung histology showed evidence of fibrosis, suggesting sequelae of SARS-CoV-2 infection. Our findings indicate that specific effectors of the immune response in the lung and spleen were either increased or depleted in response to doses of SARS-CoV-2. This study demonstrated that the response of local and systemic immune effectors to a viral infection varies with viral dose, which either exacerbates the severity of the infection or accelerates its elimination.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Comparison of susceptible and resistant SARS-CoV-2 mouse models on FVB background
한국실험동물학회 학술발표대회 논문집
2022 .01
-
Effect of SARS-CoV-2 and Streptococcus pneumoniae co-Infection on immune response in the hACE2 transgenic mouse
한국실험동물학회 학술발표대회 논문집
2025 .02
-
Effect of SARS-CoV-2 on embryonic implantation and development in the K18-hACE2 transgenic mouse model
한국실험동물학회 학술발표대회 논문집
2022 .01
-
A mouse model for SARS-CoV-2 infection using adeno-associated virus encoding hACE2
한국실험동물학회 학술발표대회 논문집
2022 .01
-
SARS-CoV-2-Specific T Cell Responses in Patients with COVID-19 and Unexposed Individuals
Immune Network
2021 .02
-
Effect of genetic background differences between FVB and C57BL/6 mice in SARS-CoV-2 infection
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Experimental Animal Models of Coronavirus Infections: Strengths and Limitations
Immune Network
2021 .04
-
Molecular pathogenesis of SARS-CoV-2 in animal model
한국실험동물학회 학술발표대회 논문집
2022 .01
-
Viral Load Kinetics of SARS-CoV-2 Infection in First Two Patients in Korea
Journal of Korean Medical Science
2020 .01
-
Impaired dendritic cell-mediated immunity in lymphoid organs may underlie the high brain viral load to determine lethality in SARS-CoV-2-infected K18-hACE2 mice
한국실험동물학회 학술발표대회 논문집
2022 .01
-
Virus Isolation from the First Patient with SARS-CoV-2 in Korea
Journal of Korean Medical Science
2020 .01
-
Empirical Treatment and Prevention of COVID-19
Infection and Chemotherapy
2020 .01
-
Development of a screening platform to discover natural products active against SARS-CoV-2 infection using lung organoid models
생체재료학회지
2023 .03
-
Isolation and Genomic Analyses of an Early SARS-CoV-2 Strains from the 2020 Epidemic in Gwangju, South Korea
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2021 .09
-
Response to Usefulness of the Rapid Antigen Test in Detecting SARS-CoV-2 for Infection Control in Hospitals
Infection and Chemotherapy
2024 .06
-
Understanding the Host Innate Immune Responses against SARS-CoV-2 Infection and COVID-19 Pathogenesis
Immune Network
2021 .02
-
Detection and Isolation of SARS-CoV-2 in Serum, Urine, and Stool Specimens of COVID-19 Patients from the Republic of Korea
Osong Public Health and Research Persptectives
2020 .01
-
Lessons Learned from SARS-CoV and MERS-CoV: Preparation for SARS-CoV-2 induced COVID-19
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2020 .06
-
Ginseng, a promising choice for SARS-COV-2: A mini review
Journal of Ginseng Research
2022 .03
-
[A-2] SARS-CoV-2 Omicron variant causes brain infection with lymphoid depletion in a mouse COVID-19 model
한국실험동물학회 학술발표대회 논문집
2024 .07
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-151-25-02-091068511