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논문 기본 정보

자료유형
학술저널
저자정보
Hyunseo Lim (Yonsei University College of Medicine) Young Ho Choe (Yonsei University College of Medicine) Jaeho Lee (Yonsei University College of Medicine) Gi Eun Kim (Yonsei University College of Medicine) Jin Won Hyun (Jeju National University College of Medicine) Young-Min Hyun (Yonsei University College of Medicine)
저널정보
대한면역학회 Immune Network Immune Network Vol.24 No.3
발행연도
2024.6
수록면
104 - 117 (14page)

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초록· 키워드

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Adipose tissue, well known for its endocrine function, plays an immunological role in the body. The inflamed adipose tissue under LPS-induced systemic inflammation is characterized by the dominance of pro-inflammatory immune cells, particularly neutrophils. Although migration of macrophages toward damaged or dead adipocytes to form a crownlike structure in inflamed adipose tissue has been revealed, the neutrophilic interaction with adipocytes or the extracellular matrix remains unknown. Here, we demonstrated the involvement of adhesion molecules, particularly integrin α6β1, of neutrophils in adipocytes or the extracellular matrix of inflamed adipose tissue interaction. These results suggest that disrupting the adhesion between adipose tissue components and neutrophils may govern the accumulation of excessive neutrophils in inflamed tissues, a prerequisite in developing antiinflammatory therapeutics by inhibiting inflammatory immune cells.

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ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES

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