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논문 기본 정보

자료유형
학술저널
저자정보
Han Hee Jo (Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.) Kim Seung Woo (Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.) Kim Hyunjin (Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) So Jungmin (Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) Lee Eun-Jae (Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) Lim Young-Min (Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) Lee Jung Hwan (Department of Neurology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.) Lee Myung Ah (Department of Neurology, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.) Kim Byung-Jo (Department of Neurology, Korea University Anam Hospital, Seoul, Korea.) Baek Seol-Hee (Department of Neurology, Korea University Anam Hospital, Seoul, Korea.) Lee Hyung-Soo (Department of Neurology, National Medical Center, Seoul, Korea.) Sohn Eunhee (Department of Neurology, Chungnam National University Hospital, Chungnam National University College of Medicine, Daejeon, Korea.) Kim Sooyoung (Department of Neurology, Chungnam National University Hospital, Chungnam National University College of Medicine, Daejeon, Korea.) Park Jin-Sung (Department of Neurology, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.) Kang Minsung (Department of Neurology, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.) Park Hyung Jun (Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.) Yoon Byeol-A (Department of Neurology, Dong-A University College of Medicine, Busan, Korea.) Kim Jong Kuk (Department of Neurology, Dong-A University College of Medicine, Busan, Korea.) Seok Hung Youl (Department of Neurology, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea.) Kim Sohyeon (Department of Neurology, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea.) Min Ju-Hong (Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.) Chung Yeon Hak (Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.) Cho Jeong Hee (Department of Neurology, National Health Insurance Service Ilsan Hospital, Goyang, Korea.) Kim Jee-Eun (Department of Neurology, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Korea.) Oh Seong-il (Department of Neurology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Korea.) Shin Ha Young (Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.39 No.18
발행연도
2024.5
수록면
1 - 11 (11page)
DOI
10.3346/jkms.2024.39.e150

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초록· 키워드

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Background: During the coronavirus disease 2019 (COVID-19) pandemic, patients with myasthenia gravis (MG) were more susceptible to poor outcomes owing to respiratory muscle weakness and immunotherapy. Several studies conducted in the early stages of the COVID-19 pandemic reported higher mortality in patients with MG compared to the general population. This study aimed to investigate the clinical course and prognosis of COVID-19 in patients with MG and to compare these parameters between vaccinated and unvaccinated patients in South Korea. Methods: This multicenter, retrospective study, which was conducted at 14 tertiary hospitals in South Korea, reviewed the medical records and identified MG patients who contracted COVID-19 between February 2022 and April 2022. The demographic and clinical characteristics associated with MG and vaccination status were collected. The clinical outcomes of COVID-19 infection and MG were investigated and compared between the vaccinated and unvaccinated patients. Results: Ninety-two patients with MG contracted COVID-19 during the study. Nine (9.8%) patients required hospitalization, 4 (4.3%) of whom were admitted to the intensive care unit. Seventy-five of 92 patients were vaccinated before contracting COVID-19 infection, and 17 were not. During the COVID-19 infection, 6 of 17 (35.3%) unvaccinated patients were hospitalized, whereas 3 of 75 (4.0%) vaccinated patients were hospitalized (P < 0.001). The frequencies of ICU admission and mechanical ventilation were significantly lower in the vaccinated patients than in the unvaccinated patients (P = 0.019 and P = 0.032, respectively). The rate of MG deterioration was significantly lower in the vaccinated patients than in the unvaccinated patients (P = 0.041). Logistic regression after weighting revealed that the risk of hospitalization and MG deterioration after COVID-19 infection was significantly lower in the vaccinated patients than in the unvaccinated patients. Conclusion: This study suggests that the clinical course and prognosis of patients with MG who contracted COVID-19 during the dominance of the omicron variant of COVID-19 may be milder than those at the early phase of the COVID-19 pandemic when vaccination was unavailable. Vaccination may reduce the morbidity of COVID-19 in patients with MG and effectively prevent MG deterioration induced by COVID-19 infection.
#Myasthenia Gravis #COVID-19 Infection #Vaccination #Outcomes #Worsening

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