지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2025.2
- 수록면
- 32 - 37 (6page)
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Backgrounds/Aims: Liver transplantation (LT) is now a critical, life-saving treatment for patients with liver cirrhosis or hepatocel- lular carcinoma. Despite its significant benefits, biliary complications (BCs) continue to be a major cause of postoperative morbidity.
This study evaluates the fluorescence intensity (FI) of the common bile duct (CBD) utilizing near-infrared indocyanine green (ICG) imaging, and examines its association with the incidence of BCs within three months post-LT.
Methods: This investigation analyzed data from nine living donor LT (LDLT) recipients who were administered 0.05 mg/kg of ICG prior to bile duct anastomosis. Real-time perfusion of the CBD was recorded for three minutes using an ICG camera, and FI was quan- tified using Image J (National Institutes of Health). Key parameters assessed included F max, F<sub>1/2</sub> max, T<sub>1/2</sub> max, and the slope (F max/ T max) to evaluate the fluorescence response.
Results: BCs occurred in two out of nine patients. These two patients exhibited the longest T<sub>1/2</sub> max values, which were linked with lower slope values, implicating a potential relationship between extended T<sub>1/2</sub> max, reduced slope, and the occurrence of postoperative BCs.
Conclusions: The study indicates that ICG fluorescence imaging may serve as an effective tool for assessing bile duct perfusion in LDLT patients. While the data suggest that an extended T<sub>1/2</sub> max and lower slope may correlate with an increased risk of BCs, further validation through larger studies is required to confirm the predictive value of ICG fluorescence imaging in this setting.
This study evaluates the fluorescence intensity (FI) of the common bile duct (CBD) utilizing near-infrared indocyanine green (ICG) imaging, and examines its association with the incidence of BCs within three months post-LT.
Methods: This investigation analyzed data from nine living donor LT (LDLT) recipients who were administered 0.05 mg/kg of ICG prior to bile duct anastomosis. Real-time perfusion of the CBD was recorded for three minutes using an ICG camera, and FI was quan- tified using Image J (National Institutes of Health). Key parameters assessed included F max, F<sub>1/2</sub> max, T<sub>1/2</sub> max, and the slope (F max/ T max) to evaluate the fluorescence response.
Results: BCs occurred in two out of nine patients. These two patients exhibited the longest T<sub>1/2</sub> max values, which were linked with lower slope values, implicating a potential relationship between extended T<sub>1/2</sub> max, reduced slope, and the occurrence of postoperative BCs.
Conclusions: The study indicates that ICG fluorescence imaging may serve as an effective tool for assessing bile duct perfusion in LDLT patients. While the data suggest that an extended T<sub>1/2</sub> max and lower slope may correlate with an increased risk of BCs, further validation through larger studies is required to confirm the predictive value of ICG fluorescence imaging in this setting.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
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