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논문 기본 정보

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학술저널
저자정보
장영훈 (분당서울대학교병원 내과) 신철민 (분당서울대학교병원) 한경도 (숭실대학교) 정진형 (가톨릭대학교) 진은효 (서울대학교병원) 임주현 (서울대학교) 강승주 (서울대학교병원) 최윤진 (서울대학교) 윤혁 (서울대학교) 박영수 (분당서울대학교병원) 김나영 (서울대학교병원) 이동호 (서울대학교병원)
저널정보
대한암학회 Cancer Research and Treatment Cancer Research and Treatment Vol.56 No.3
발행연도
2024.7
수록면
825 - 837 (13page)
DOI
10.4143/crt.2023.753

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Purpose The incidence of early-onset colorectal cancer (EoCRC) is increasing worldwide. The association between hypertriglyceridemia (HTG) and EoCRC risk remains unclear. Materials and Methods We conducted a nationwide cohort study of 3,340,635 individuals aged 20-49 years who underwent health checkups between 2009 and 2011 under the Korean National Health Insurance Service. HTG was defined as serum triglyceride (TG) level ≥ 150 mg/dL. According to the change in TG status, participants were categorized into persistent normotriglyceridemia (NTG; group 1), NTG to HTG (group 2), HTG to NTG (group 3), and persistent HTG (group 4) groups. The EoCRC incidence was followed up until 2019. Results In total, 7,492 EoCRC cases developed after a mean of 6.05 years of follow-up. Group 4 had the highest risk of EoCRC (adjusted hazard ratio [aHR], 1.097; 95% confidence interval [CI], 1.025 to 1.174). While the risk of rectal cancer was significantly increased in groups 3 and 4 (aHR [95% CI], 1.236 [1.076 to 1.419] and 1.175 [1.042-1.325], respectively), no significant risk differences were observed in right colon cancer. In group 4, male sex and diabetes were associated with a further increased risk of EoCRC (aHR [95% CI], 1.149 [1.082 to 1.221] and 1.409 [1.169 to 1.699], respectively). In addition, there was a dose-response relationship between serum TG levels and the risk of EoCRC (p for trends < 0.0001). Conclusion Persistent HTG increased the risk of EoCRC, which was significantly higher only for rectal cancer and marginally higher for other colonic subsites.

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