지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.6
- 수록면
- 8 - 17 (10page)
- DOI
- 10.5049/EBP.2023.21.1.8
이용수
초록· 키워드
오류제보하기
Fabry disease (FD), a rare X-linked lysosomal storage disorder that depletes alpha-galac tosidase A (α-GalA), is caused by mutations in the GLA gene. Diminished α-GalA enzyme activity results in the accumulation of Gb3 and lyso-Gb3. The pathophysiology of hypertension in FD is complex and unclear. The storage of Gb3 in arterial endothelial cells and smooth muscle cells is known to produce vascular injury by increasing oxidative stress and inflammatory cytokines as a primary pathophysio logical mechanism. In addition, Fabry nephropathy developed, resulting in a decrease in kidney function and contributing to hypertension.
The prevalence of hypertension in patients with FD was between 28.4% and 56%, whereas hypertension in patients with chronic kidney disease ranged between 33% and 79%. A study using 24-hour ambulatory blood pressure monitoring (ABPM) to measure blood pressure (BP) indicated a high prevalence of uncontrolled hyper tension in FD. Thus, 24-hour ABPM ought to be considered for FD hypertension assessments.
Appropriate treatment of hypertension is believed to reduce mortality in patients with FD caused by kidney disease, cardiovascular disease, and cerebrovascular disease because hypertension significantly impacts organ damage. Up to 70% of FD patients have been reported to have kidney involvement, and angiotensin converting enzyme inhibitors and angiotensin receptor blockers prescribed for proteinuria are recommended as first-line therapy with antihypertensive drugs.
In conclusion, hypertension should be controlled appropriately, given the different morbidity and mortality caused by significant organ involvement in FD patients.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Korea hypertension fact sheet 2022: analysis of nationwide population-based data with a special focus on hypertension in the elderly
Clinical Hypertension
2023 .01
-
2018 Korean Society of Hypertension guidelines for the management of hypertension: part I-epidemiology of hypertension
Clinical Hypertension
2019 .01
-
Chronic Management of Hypertension after Stroke: The Role of Ambulatory Blood Pressure Monitoring
대한뇌졸중학회지
2016 .01
-
Angiotensin-(1-9) ameliorates pulmonary arterial hypertension via angiotensin type II receptor
The Korean Journal of Physiology & Pharmacology
2018 .07
-
Prevalence of Masked Hypertension: a Population-Based Survey in a Large City by Using 24-Hour Ambulatory Blood Pressure Monitoring
Korean Circulation Journal
2016 .01
-
Application of artificial intelligence in hypertension
Clinical Hypertension
2024 .01
-
Korea hypertension fact sheet 2020: analysis of nationwide population-based data
Clinical Hypertension
2021 .01
-
만성 콩팥병 환자에서 고혈압의 진단 기준 Update: 2017 ACC/AHA 고혈압 가이드라인의 적용
대한내과학회지
2019 .06
-
Highlights of the 2018 Chinese hypertension guidelines
Clinical Hypertension
2020 .01
-
A 2020 Vision of Hypertension
Korean Circulation Journal
2020 .01
-
2013 Korean Society of Hypertension guidelines for the management of hypertension. Part III—hypertension in special situations
Clinical Hypertension
2015 .01
-
Sex-Specific Trends in the Prevalence of Hypertension and the Number of People With Hypertension: Analysis of the Korea National Health and Nutrition Examination Survey (KNHANES) 1998?2018
Korean Circulation Journal
2022 .05
-
When and how to use ambulatory blood pressure monitoring and home blood pressure monitoring for managing hypertension
Clinical Hypertension
2024 .01
-
2018 Korean society of hypertension guidelines for the management of hypertension: part III-hypertension in special situations
Clinical Hypertension
2019 .01
-
Gender Differences in Hypertension Control Among Older Korean Adults: Korean Social Life, Health, and Aging Project
예방의학회지
2015 .01
-
Updated Reasons and Clinical Implications of New Korean Hypertension Guidelines for Cardiologists
Korean Circulation Journal
2020 .01
-
Korea hypertension fact sheet 2021: analysis of nationwide population-based data with special focus on hypertension in women
Clinical Hypertension
2022 .01
-
The 2022 focused update of the 2018 Korean Hypertension Society Guidelines for the management of hypertension
Clinical Hypertension
2023 .01
-
Refractory and Resistant Hypertension: Antihypertensive Treatment Failure versus Treatment Resistance
Korean Circulation Journal
2016 .01
-
Resistant hypertension: consensus document from the Korean society of hypertension
Clinical Hypertension
2023 .01
최근 본 자료
댓글(0)
0