지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.7
- 수록면
- 398 - 406 (9page)
- DOI
- https://doi.org/10.4070/kcj.2024.0084
이용수
초록· 키워드
오류제보하기
Background and Objectives: Optimal anticoagulation in very elderly patients is challenging due to the high risk of anticoagulant-induced bleeding. The aim of this study was to assess outcomes of on-label reduced-dose edoxaban (30 mg) in very elderly patients who had additional risk factors for bleeding.
Methods: This was a multi-center, prospective, non-interventional observational study to evaluate the efficacy and safety of on-label reduced-dose edoxaban in atrial fibrillation (AF) patients 80 years of age or older and who had more than 1 risk factor for bleeding.
Results: A total of 2448 patients (mean age 75.0±8.3 years, 801 [32.7%] males) was included in the present study, and 586 (23.9%) were 80 years of age or older with additional risk factors for bleeding. Major bleeding events occurred frequently among very elderly AF patients who had additional bleeding risk factors compared to other patients (unadjusted hazard ratio [HR], 2.16; 95% confidence interval [CI], 1.16–4.02); however, there were no significant differences in stroke incidence (HR, 1.86; 95% CI, 0.98–3.55). There were no significant differences for either factor after adjusting for age and sex (adjusted HR, 1.65; 95% CI, 0.75–3.62 for major bleeding; adjusted HR, 1.13; 95% CI, 0.51–2.50 for stroke).
Conclusions: In very elderly AF patients with comorbidities associated with greater risk of bleeding, the incidence of major bleeding events was significantly increased. In addition, risk of stroke showed tendency to increase in same population. Effective anticoagulation therapy might be important in these high-risk population, and close observation of bleeding events might also be required.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Stroke and Bleeding Risk Assessment in Atrial Fibrillation: Where Are We Now?
Korean Circulation Journal
2021 .01
-
출혈시간 검사에 대한 임상적 유용성: 체계적 문헌고찰
보건의료기술평가
2022 .12
-
Stroke Prevention in Atrial Fibrillation: Focus on Asian Patients
Korean Circulation Journal
2018 .01
-
Anticoagulation in Patients with End-Stage Renal Disease and Atrial Fibrillation: Confusion, Concerns and Consequences
대한뇌졸중학회지
2020 .01
-
A practical approach for small bowel bleeding
Clinical Endoscopy
2023 .05
-
Efficacy of Multidisciplinary Clinical Pathway for the Management of Postpartum Hemorrhage
Perinatology
2019 .01
-
Strategies that Reduce Post-endoscopic Submucosal Dissection Bleeding
Korean Journal of Helicobacter Upper Gastrointestinal Research
2021 .09
-
Frequency and risk factors of severe postoperative bleeding after proctological surgery: a retrospective case-control study
Annals of Coloproctology
2022 .10
-
2021 대한부정맥학회 심방세동 환자의 뇌졸중 예방 관리 지침
대한내과학회지
2021 .08
-
상부위장관 출혈로 내원한 정상 혈압 환자에서 활동성 출혈을 예측하기 위한 Glasgow Blatchford score, Pre-Rockall score, AIMS65 score의 유용성 검정 및 새로운 예측인자 개발을 위한 제언
대한응급의학회지
2019 .01
-
Is the Modified AIMS65 Score Suitable for Distinguishing the Low Risk Group and the High Risk Group for Patients with Upper Gastrointestinal Bleeding?
대한응급의학회지
2017 .01
-
심방세동과 말기 콩팥병이 동반된 환자에서 와파린과 항혈소판 요법의 안전성과 효과 비교
대한내과학회지
2019 .04
-
The Time of Endoscopy for Nonvariceal Upper Gastrointestinal Bleeding: An Observational Study
Korean Journal of Helicobacter Upper Gastrointestinal Research
2024 .09
-
Hemorrhoidectomy for Patients with High Risk of Bleeding
대한외과학회 학술대회 초록집
2018 .11
-
2018 대한부정맥학회 심방세동 환자에서 NOAC 사용 지침: 출혈의 대처와 수술 전후 복약관리
대한내과학회지
2019 .02
-
Predicting the Bleeding Risk for Patients on Anticoagulant Therapy Prior to Gastric Endoscopic Submucosal Dissection
Journal of Gastric Cancer
2022 .03
-
Rare bleeding disorders: spectrum of disease and clinical manifestations in the Pakistani population
Blood Research
2020 .01
-
Could a bleeding-sensor device be established as a new paradigm for detecting upper gastrointestinal bleeding before performing endoscopy?
Clinical Endoscopy
2024 .03
-
A novel concept on volumetric assessment and quantification of gastrointestinal bleed on computed tomography angiography: Observations based on a case series
Annals of Hepato-Biliary-Pancreatic Surgery
2021 .02
-
Delayed bleeding after implant surgery in patients taking novel oral anticoagulants: a case report
Journal of dental anesthesia and pain medicine
2017 .01
최근 본 자료
댓글(0)
0