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논문 기본 정보

자료유형
학술저널
저자정보
Sim Soyoon (Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.Department of Biomedical Sciences, Ajou University School of Medicine, Suwon, Korea.) Choi Youngwoo (Department of Biomaterials Science (BK21 FOUR Program), College of Natural Resources and Life Science, Pusan National University, Miryang, Korea.) Park Hae-Sim (Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.Department of Biomedical Sciences, Ajou University School of Medicine, Suwon, Korea.)
저널정보
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research AAIR Vol.16 No.5
발행연도
2024.9
수록면
462 - 472 (11page)
DOI
10.4168/aair.2024.16.5.462

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초록· 키워드

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Asthma is a chronic heterogeneous disease characterized by various symptoms and persistent airway inflammation, resulting in progressive lung function decline. Classifying asthma phenotypes/endotypes is crucial because the underlying mechanisms and long-term outcomes vary from patient to patient. Recent trials have identified several biomarkers for classifying asthma phenotypes/endotypes, and current treatments have been developed on the basis of these biomarkers. Conventional biomarkers, including immunoglobulin E, blood/sputum eosinophil counts, airway obstruction or reversibility, and fractional exhaled nitric oxide, are widely used to diagnose asthma. However, these markers have some limitations, necessitating the discovery of additional biomarkers. Therefore, this review summarizes recently suggested biomarkers for representing type 2-high (eosinophilic) vs. type 2-low (neutrophilic) asthma, non-steroidal anti-inflammatory drug-exacerbated respiratory disease, and severe asthma. Additionally, we discuss the potential benefits of these biomarkers in classifying specific phenotypes/endotypes and managing asthmatic patients.

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