지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.7
- 수록면
- 400 - 410 (11page)
- DOI
- https://doi.org/10.4111/icu.20240077
이용수
초록· 키워드
오류제보하기
Purpose: To determine whether the overexpression of the Argonaute RNA-induced silencing complex catalytic component 2 (Ago2) improves erectile function in mice after cavernous nerve injury (CNI).
Materials and Methods: Lentiviruses containing Ago2 open reading frame (ORF) mouse clone (Ago2 O/E) were used to overexpress Ago2, and lentiviruses ORF negative control particles (NC) were used as a negative control. Three days before preparing the CNI model, we injected lentiviruses into the penises of 8-week-old male C57BL/6 mice. Animals were then divided into four groups: the sham operation control group and the CNI+phosphate-buffered saline, CNI+NC, and CNI+Ago2 O/E groups. One week later, erectile function was assessed by electrically stimulating cavernous nerves bilaterally and obtaining intracavernous pressure parameters. Penile tissue was also collected for molecular mechanism studies.
Results: Ago2 overexpression improved erectile function in mice after CNI-induced erectile dysfunction (ED). Immunofluorescence staining and Western blot analysis showed that under Ago2 overexpressing conditions, the contents of endothelial cells, pericytes, and neuronal cells increased in the penile tissues of CNI mice, and this was attributed to reduced apoptosis and ROS production. In addition, we also found that Ago2 overexpression could restore penile mitochondrial function, thereby improving erectile function in CNI-induced ED mice.
Conclusions: Our findings demonstrate that Ago2 overexpression can reduce penile cell apoptosis, restore penile mitochondrial function, and improve erectile function in CNI-induced ED mice.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Gene expression profile comparison in the penile tissue of diabetes and cavernous nerve injury-induced erectile dysfunction rat model
Investigative and Clinical Urology
2016 .01
-
Can malleable penile prosthesis implantation improve voiding dysfunction in men with concurrent erectile dysfunction and buried penis?
Investigative and Clinical Urology
2021 .01
-
Evolution of penile prosthetic devices
Investigative and Clinical Urology
2015 .01
-
Penile circumference and stretched penile length in prepubertal children: A retrospective, single-center pilot study
Investigative and Clinical Urology
2021 .01
-
Mondor’s Disease of the Penis Mistaken for Penile Fracture
Urogenital Tract Infection
2016 .01
-
The Effect of the Combination of Ginseng, Tribulus Terrestris, and L-arginine on the Sexual Performance of Men with Erectile Dysfunction: a randomized, double-blind, parallel, and placebo-controlled clinical trial
Journal of Pharmacopuncture
2024 .06
-
Penile Doppler ultrasonography revisited
ULTRASONOGRAPHY
2018 .01
-
Pericyte-derived heme-binding protein 1 promotes angiogenesis and improves erectile function in diabetic mice
Investigative and Clinical Urology
2022 .07
-
Penile Strangulation: A Novel Surgical Procedure without Cutting Equipment
Urogenital Tract Infection
2020 .01
-
Scrotal septum detachment during penile plication to compensate for loss of penile length compared with conventional surgical technique
Investigative and Clinical Urology
2020 .01
-
Impact of calcineurin inhibitors on rat glioma cells viability
Journal of Yeungnam Medical Science
2019 .01
-
Long-term survival and patient satisfaction with inflatable penile prosthesis for the treatment of erectile dysfunction
Investigative and Clinical Urology
2015 .01
-
Effects of Omega-3 Fatty Acids on Erectile Dysfunction in a Rat Model of Atherosclerosis-induced Chronic Pelvic Ischemia
Journal of Korean Medical Science
2016 .01
-
Use of nanoparticles to monitor human mesenchymal stem cells transplanted into penile cavernosum of rats with erectile dysfunction
Investigative and Clinical Urology
2015 .01
-
Ginsenoside Re Enriched Fraction (GS-F3K1) from Ginseng Berries Ameliorates Ethanol-Induced Erectile Dysfunction via Nitric Oxide-cGMP Pathway
Natural Product Sciences
2016 .03
-
A mouse model with genetic defect of mitochondrial complex I to study neurodegeneration
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Penile skin preservation technique for reconstruction surgery of penile paraffinoma
Investigative and Clinical Urology
2019 .01
-
Penile inversion through a penoscrotal incision for the treatment of penile urethral strictures
Investigative and Clinical Urology
2016 .01
-
Prolonged oral sildenafil use-induced Mondor disease: a case report
Journal of Yeungnam Medical Science
2022 .07
-
From breeding mouse to editing mouse genome
한국실험동물학회 학술발표대회 논문집
2017 .08
최근 본 자료
댓글(0)
0