지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.6
- 수록면
- 38 - 49 (12page)
이용수
초록· 키워드
오류제보하기
Objectives: This study aims to compare the effectiveness of individualized antiplatelet therapy guided by platelet drug response assay (PDRA, VerifyNow) in patients with antiplatelet therapy.
Methods: Systematic searches on OVID-MEDLINE, Embase, Cochrane Library and 5 Korean databases were performed. Randomized controlled trials (RCTs) was included and a pooled metaanalysis were conducted. The outcomes of interest were ischemic events and bleeding. Results: A total of four RCTs comprising 3,697 patients with coronary artery disease undergoing percutaneous coronary intervention were included in the analysis. Overall risk of bias were ‘low’ but the risk of the allocation concealment were ‘unclear’ in three studies. Compared to the standard antiplatelet therapy, the individualized antiplatelet therapy by PDRA did not decrease the overall mortality (risk ratio [RR] 0.99, 95% confidence interval [CI] 0.48–2.04, I2=66%). It was not available to conduct meta-analysis on cardiovascular mortality, myocardial infarction, and strokes, but there were no significance between the intervention and comparator groups in each study. Also, there was no significant difference in bleeding regardless of the severity (RR 0.85, 95% CI 0.69–1.05, I2=28%). Conclusion: This study demonstrated that the individualzed antiplatelet therapy guided by PDRA did not improve the outcomes including ischemic events or bleeding compared to the standard therapy.
Due to the heterogeneity and divergence among the studies, further RCTs are still needed examining the results.
Keywords Platelet
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
클로피도그렐 또는 티카그렐러로 치료받는 환자에서 혈소판 수와 특성이 혈소판 반응성에 미치는 영향
대한내과학회지
2017 .01
-
Effectiveness of Platelet Function Analyzer-100 for Laboratory Detection of Anti-Platelet Drug-Induced Platelet Dysfunction
Annals of Laboratory Medicine
2019 .01
-
Mean Platelet Volume and Mean Platelet Volume/Platelet Count Ratio in Chronic Urticaria
Annals of Dermatology
2019 .01
-
Temporal Variability of Platelet Reactivity Phenotype: Another Barrier to Personalized Antiplatelet Strategy Guided by Platelet Function Testing
Korean Circulation Journal
2019 .01
-
Variability of Platelet Reactivity on Antiplatelet Therapy in Neurointervention Procedure
대한신경외과학회지
2019 .01
-
Thapsigargin Induces Platelet Aggregation, thereby Releases Lactate Dehydrogenase from Rat Platelets
대한의생명과학회지
2021 .09
-
Effects and treatment applications of polymeric nanoparticles on improving platelets’ storage time: a review of the literature from 2010 to 2020
Blood Research
2021 .12
-
Characterization of the distinct mechanism of agonist-induced canine platelet activation
Journal of Veterinary Science
2019 .01
-
Evaluation of Platelet Indices in Lung Cancer Patients
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Bleeding time: Remained or Retired or Removed?
Laboratory Medicine Online
2023 .01
-
Expanded Impacts of Platelet Functions: Beyond Hemostasis and Thrombosis
Annals of Laboratory Medicine
2019 .01
-
The anti-platelet activity of panaxadiol fraction and panaxatriol fraction of Korean Red Ginseng in vitro and ex vivo
Journal of Ginseng Research
2023 .09
-
Antiplatelet Effects of Garlic and Chitosan : a Comparative Study between Fermented and Non-Fermented Preparations
대한의생명과학회지
2018 .09
-
Anti-platelet role of Korean ginseng and ginsenosides in cardiovascular diseases
Journal of Ginseng Research
2020 .01
-
Platelet-rich plasma, platelet derivatives, and their therapeutic importance in veterinary medicine
Journal of Biomedical and Translational Research
2022 .12
-
Arsenic induces platelet shape change through altering focal adhesion kinase-mediated actin dynamics
환경독성보건학회 심포지엄 및 학술대회
2021 .05
-
혈소판 풍부 혈장의 주사치료
대한정형외과학회지
2018 .10
-
Platelet Shape Changes and Cytoskeleton Dynamics as Novel Therapeutic Targets for Anti-Thrombotic Drugs
Biomolecules & Therapeutics(구 응용약물학회지)
2017 .01
-
Possible roles of platelets in liver transplantation: regeneration and cancer recurrence
Anesthesia and Pain Medicine
2021 .01
-
Current Knowledge on Inherited Platelet Function Disorders
Clinical Pediatric Hematology-Oncology
2020 .01
최근 본 자료
댓글(0)
0