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논문 기본 정보

저자정보
(서원대학교)
저널정보
한국생약학회 생약학회지(Korean Journal of Pharmacognosy) 생약학회지 제56권 제2호
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    초록·키워드

    Hair loss is a significant concern in modern society, often leading to psychological stress and low self-esteem. This study explores the potential of isoalantolactone (ISA), a natural compound, as a preventive and therapeutic agent for hair loss. ISA activates the WNT/β-catenin signaling pathway, which plays a crucial role in hair follicle regeneration and growth, and promotes the proliferation of hHDFP cells. Additionally, ISA enhances hair cell growth by upregulating Erk1/2, a key component of the RAS/MAPK pathway, and indirectly prevents β-catenin degradation by regulating WNT signaling, thereby accelerating early hair growth. In a C57BL/6 mouse model, ISA administration significantly improved hair growth and increased hair thickness compared to the control group. These findings suggest that ISA may serve as a promising novel treatment for hair loss by stimulating hair growth.

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