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자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
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Citeasy
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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
피인용 0
초록·키워드
This study investigated the effects of heat-treated Liriope platyphylla ethanol extract (LP) on the expression of chemokines and skin barrier-related genes in HaCaT cells stimulated with TNF-α/IFN-γ to induce atopic dermatitis (AD). The impact of LP on cell viability was assessed using the WST assay, leading to the selection of a non-cytotoxic concentration of ≤100 μg/mL for further experiments. LP’s efficacy was evaluated by measuring the mRNA expression of inflammatory chemokines (CCL17, CCL22, CCL5), cytokine levels (IL-6, IL-1β), and skin barrier-related factors (FLG, LOR). The phosphorylation of NF-κB p65 was also analyzed via Western blot. LP treatment significantly reduced the mRNA expression of inflammatory chemokines (CCL17, CCL22, CCL5) and cytokines (IL-6, IL-1β), which were notably upregulated by TNF-α/IFN-γ stimulation. Additionally, the expression of skin barrier-related genes, such as FLG and LOR, which had decreased due to inflammatory stimulation, was significantly and dose-dependently restored following LP treatment. Furthermore, LP treatment inhibited the activation of TNF-α/IFN-γ-induced NF-κB signaling pathways. These findings suggest that LP has potential as a functional material for preventing and managing atopic dermatitis by reducing inflammation and restoring the skin barrier.
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UCI(KEPA) : I410-151-26-02-095669144
