인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
피인용 0
초록·키워드
Neuroinflammation is a major contributor to the pathogenesis of neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. A key mediator of this process is the NLRP3 inflammasome in microglia, which activates caspase-1 and drives the maturation and release of pro-inflammatory cytokines including IL-1β. Excessive or sustained activation of the NLRP3 inflammasome promotes neuronal dysfunction, highlighting it as a potential therapeutic target. Ginsenoside Rg1, a predominant bioactive compound of Panax ginseng C. A. Meyer, is known for its antioxidant and anti-inflammatory properties; however, its direct role in regulating NLRP3 remains poorly understood. In this study, we examined the effects of Rg₁ on NLRP3 expression and IL-1β production in BV2 microglial cells. MTT assay confirmed that Rg₁ up to 300 μg/mL had no cytotoxic effect. Western blot analysis demonstrated that Rg1 pretreatment significantly suppressed LPS-induced NLRP3 protein expression and reduced IL-1β levels, whereas qPCR analysis revealed no change in NLRP3 mRNA expression. These findings suggest that Rg1 regulates NLRP3 at the post-transcriptional level. Consistent with this, the DARTS assay indicated a direct binding interaction between Rg₁ and NLRP3. Taken together, these results identify ginsenoside Rg₁ as a promising candidate for the prevention or treatment of neuroinflammatory diseases.
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UCI(KEPA) : I410-151-26-02-095631168
