인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
피인용 0
초록·키워드
This study aimed to investigate the effects of exercise type (uphill vs. downhill) and muscle fiber type (fast-twitch vs. slow-twitch) on the expression of autophagy-related proteins (ATG-5, Beclin-1, LC3-I/II, p62) in aged skeletal muscles of rats. Male Sprague–Dawley rats were divided into four groups: young control (YC, n=10, 8weeks), old control (OC, n=10, 60weeks), old-uphill exercise (Ex2, n=10), and old-downhill exercise (Ex1, n=10). The exercise groups performed treadmill endurance training for eight weeks. After the training, the extensor digitorum longus (EDL) and soleus (SOL) muscles were extracted, and protein expression was analyzed using western blotting. The OC group showed a significant decrease in ATG-5, Beclin-1, and LC3-II expression and an increase in p62 compared with YC (p<.05), indicating reduced autophagic activity. Both exercise groups demonstrated significant recovery of these indices, with the uphill group (Ex2) showing greater improvements than the downhill group (Ex1) (p<.05). Furthermore, the recovery was more pronounced in the slow-twitch dominant SOL than in the fast-twitch dominant EDL. These findings suggest that regular endurance exercise can restore impaired autophagy in aged skeletal muscles, and that uphill (concentric) exercise is particularly effective in improving autophagic function associated with aging.
본문·목차
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최근 본 자료 전체보기
UCI(KEPA) : I410-151-26-02-095541918
