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자료유형
학술저널
저자정보
저널정보
대한영상의학회 Korean Journal of Radiology (KJR) Korean journal of radiology : official journal of the Korean Radiological Society Vol.13 No.4
발행연도
수록면
434 - 442 (9page)
DOI
http://dx.doi.org/10.3348/kjr.2012.13.4.434

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초록· 키워드

<P><B>Objective</B></P><P>To investigate the value of spectral CT imaging in the diagnosis and classification of liver cirrhosis during the arterial phase (AP) and portal venous phase (PVP).</P><P><B>Materials and Methods</B></P><P>Thirty-eight patients with liver cirrhosis (Child-Pugh class A/B/C: n = 10/14/14), and 43 patients with healthy livers, participated in this study. The researchers used abdominal spectral CT imaging during AP and PVP. Iodine concentration, derived from the iodine-based material-decomposition image and the iodine concentration ratio (IC<SUB>ratio</SUB>) between AP and PVP, were obtained. Statistical analyses {two-sample <I>t</I> test, One-factor analysis of variance, and area under the receiver operating characteristic curve (A [z])} were performed.</P><P><B>Results</B></P><P>The mean normalized iodine concentration (NIC) (0.5 ± 0.12) during PVP in the control group was significantly higher than that in the study group (0.4 ± 0.10 on average, 0.4 ± 0.08 for Class A, 0.4 ± 0.15 for Class B, and 0.4 ± 0.06 for Class C) (All <I>p</I> < 0.05). Within the cirrhotic liver group, the mean NIC for Class C during the AP (0.1 ± 0.05) was significantly higher than NICs for Classes A (0.1 ± 0.06) and B (0.1 ± 0.03) (Both <I>p</I> < 0.05). The IC<SUB>ratio</SUB> in the study group (0.4 ± 0.15), especially for Class C (0.5 ± 0.14), was higher than that in the control group (0.3 ± 0.15) (<I>p</I> < 0.05).The combination of NIC and IC<SUB>ratio</SUB> showed high sensitivity and specificity for differentiating healthy liver from cirrhotic liver, especially in Class C cirrhotic liver.</P><P><B>Conclusion</B></P><P>Spectral CT Provides a quantitative method with which to analyze the cirrhotic liver, and shows the potential value in the classification of liver cirrhosis.</P>
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