인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.3
- 수록면
- 51 - 60 (10page)
- DOI
- 10.35607/kjoa.31.1.200703.005
이용수
초록· 키워드
The biological function of secretory leukocyte protease inhibitor (SLPD is believed to be the inhibition of elastase, cathepsin G and other protease, thereby protecting tissue from self-degradation by these enzyme, Tooth development is associated with morphological and biochernical changes of the dental papilla and enamel organ. Among the proteins involved in the development, some proteases and inhibitors have important role for reorganization of the each developing cells, The SLPI is thought as a regulating protein on the synthesis and degradation of matrix proteins, But there was no report of expression of this molecule on the tooth development, especially on the odontoblast. Therefore, the aim of this study is to verify the role and expression of the SLPI during odontogenesis and rnineralization during mouse tooth development.
From in-situ and immunohistochernical analysis, it has firstly described that the SLPI is expressed in odontoblasts during tooth development. Expression of the SLPI was increased in differentiated odontoblast than that of young odontoblast and at the same time, collagen was also observed, From these results, the expression of SLPI in odontoblast may prevent the degradation of collagen through the regulation of MMP, suggesting that the SLPI may play the important roles in odontogenesis and rnineralization.
#Secretory leukocyte protease inhibitor
#Secretory leukocyte protease inhibitor
#mouse tooth development
#mouse tooth development
#odontoblast
#odontoblast
#collagen
#collagen
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