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DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2026.6
- 수록면
- 382 - 397 (16page)
이용수
초록· 키워드
BACKGROUND: Long-term health effects of low- and no-calorie sweeteners (LNCSs) have not been established.
OBJECTIVE: This review aimed to evaluate the associations between different types of LNCSs and a wide range of health outcomes from observational studies and randomized controlled trials (RCTs).
METHODS: We systematically searched PubMed/MEDLINE, Embase, CINAHL, and Google Scholar from inception to December 2024 for meta-analyses. LNCSs were categorized into artificial sweeteners and other non-sugar sweeteners (NSSs), including non-nutritive sweeteners and sugar alcohols, along with their corresponding beverages. The A Measurement Tool Assessment Systematic Reviews 2 (AMSTAR 2) tool was used in this study. The credibility of observational evidence was evaluated using a classification system. The certainty of evidence from RCTs was evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Eligible meta-analyses were reanalyzed using random-effects models and presented as estimated odds ratios (eOR) or standard mean differences (SMDs) with 95% confidence intervals (CIs).
RESULTS: A total of 29 meta-analyses (AMSTAR 2: high, 22; moderate, 2; low, 3; and critically low, 2) with 24 observational studies and 6 RCTs, covering 50,034,327 participants, were included. Among the 135 associations, observational studies indicated that higher intake of NSSs was associated with increased risk of being overweight (eOR, 1.84; 95% CI, 1.30 to 2.61; credibility of evidence [CE], IV), having metabolic syndrome (eOR, 1.31; 95% CI, 1.21 to 1.42; CE, I), type 2 diabetes (eOR, 1.14; 95% CI, 1.02 to 1.29; CE, IV), and hypertension (eOR, 1.13; 95% CI, 1.07 to 1.19; CE, II). In contrast, RCTs showed that NSS consumption significantly decreased body weight in populations with overweight or obesity (SMD, −0.50; 95% CI, −0.70 to −0.30; GRADE, high).
CONCLUSIONS: Our findings indicate that the use of LNCSs and their corresponding beverages is associated with potential health risks and modest benefits.
상세정보 수정요청해당 페이지 내 제목·저자·목차·페이지OBJECTIVE: This review aimed to evaluate the associations between different types of LNCSs and a wide range of health outcomes from observational studies and randomized controlled trials (RCTs).
METHODS: We systematically searched PubMed/MEDLINE, Embase, CINAHL, and Google Scholar from inception to December 2024 for meta-analyses. LNCSs were categorized into artificial sweeteners and other non-sugar sweeteners (NSSs), including non-nutritive sweeteners and sugar alcohols, along with their corresponding beverages. The A Measurement Tool Assessment Systematic Reviews 2 (AMSTAR 2) tool was used in this study. The credibility of observational evidence was evaluated using a classification system. The certainty of evidence from RCTs was evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Eligible meta-analyses were reanalyzed using random-effects models and presented as estimated odds ratios (eOR) or standard mean differences (SMDs) with 95% confidence intervals (CIs).
RESULTS: A total of 29 meta-analyses (AMSTAR 2: high, 22; moderate, 2; low, 3; and critically low, 2) with 24 observational studies and 6 RCTs, covering 50,034,327 participants, were included. Among the 135 associations, observational studies indicated that higher intake of NSSs was associated with increased risk of being overweight (eOR, 1.84; 95% CI, 1.30 to 2.61; credibility of evidence [CE], IV), having metabolic syndrome (eOR, 1.31; 95% CI, 1.21 to 1.42; CE, I), type 2 diabetes (eOR, 1.14; 95% CI, 1.02 to 1.29; CE, IV), and hypertension (eOR, 1.13; 95% CI, 1.07 to 1.19; CE, II). In contrast, RCTs showed that NSS consumption significantly decreased body weight in populations with overweight or obesity (SMD, −0.50; 95% CI, −0.70 to −0.30; GRADE, high).
CONCLUSIONS: Our findings indicate that the use of LNCSs and their corresponding beverages is associated with potential health risks and modest benefits.
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목차
- ABSTRACT
- INTRODUCTION
- METHODS
- RESULTS
- DISCUSSION
- REFERENCES
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