인문학
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자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2026.6
- 수록면
- 417 - 434 (18page)
이용수
초록· 키워드
BACKGROUND/OBJECTIVES: Time-restricted feeding (TRF) is a promising dietary strategy to improve the metabolic parameters associated with obesity, but its potential benefits in obesity linked to nighttime light exposure remain largely unclear. This study examined whether chronic light exposure alone, or in combination with TRF, modulates brown adipose tissue (BAT) in lean and obese mice.
MATERIALS/METHODS: Six-week-old male C57BL/6J mice were fed a low-fat diet (LFD) or a high-fat diet (HFD) for six weeks, and were assigned to one of three experimental conditions for an additional 6 weeks: control light exposure, continuous 24-h light exposure, or 24-h light exposure combined with TRF. This yielded 6 experimental groups: LC, L24h, L24hT, HC, H24h, and H24hT.
RESULTS: Histological analyses showed that chronic light exposure alone induced BAT whitening, characterized by lipid droplet accumulation and structural disorganization, even in LFD-fed mice. This whitening occurred without a decrease in uncoupling protein 1 mRNA and protein levels, suggesting mechanisms independent of thermogenic suppression. Instead, lipid accumulation and elevated Lep mRNA expression were associated with increased expression of various inflammatory markers ( Adgre1, Itgax, and Pycard) and F4/80-positive macrophage infiltration. Importantly, TRF intervention attenuated BAT whitening and markedly suppressed the inflammatory responses, restoring the tissue structure and reducing macrophage infiltration, particularly in HFD-fed mice.
CONCLUSION: These findings suggest that TRF may have clinical implications for obese night workers by preventing BAT from shifting toward an inflammatory and metabolically dysfunctional phenotype associated with nighttime light exposure.
상세정보 수정요청해당 페이지 내 제목·저자·목차·페이지MATERIALS/METHODS: Six-week-old male C57BL/6J mice were fed a low-fat diet (LFD) or a high-fat diet (HFD) for six weeks, and were assigned to one of three experimental conditions for an additional 6 weeks: control light exposure, continuous 24-h light exposure, or 24-h light exposure combined with TRF. This yielded 6 experimental groups: LC, L24h, L24hT, HC, H24h, and H24hT.
RESULTS: Histological analyses showed that chronic light exposure alone induced BAT whitening, characterized by lipid droplet accumulation and structural disorganization, even in LFD-fed mice. This whitening occurred without a decrease in uncoupling protein 1 mRNA and protein levels, suggesting mechanisms independent of thermogenic suppression. Instead, lipid accumulation and elevated Lep mRNA expression were associated with increased expression of various inflammatory markers ( Adgre1, Itgax, and Pycard) and F4/80-positive macrophage infiltration. Importantly, TRF intervention attenuated BAT whitening and markedly suppressed the inflammatory responses, restoring the tissue structure and reducing macrophage infiltration, particularly in HFD-fed mice.
CONCLUSION: These findings suggest that TRF may have clinical implications for obese night workers by preventing BAT from shifting toward an inflammatory and metabolically dysfunctional phenotype associated with nighttime light exposure.
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목차
- ABSTRACT
- INTRODUCTION
- MATERIALS AND METHODS
- RESULTS
- DISCUSSION
- REFERENCES
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