인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2026.6
- 수록면
- 461 - 475 (15page)
이용수
초록· 키워드
BACKGROUNDS/OBJECTIVES: Child growth is affected by genetics, nutrition, physical activity, and environmental factors. Despite the improvements in average height among Korean children due to better socioeconomic and nutritional status, safe and effective growth-promoting interventions are still needed for children with mild short stature. This study evaluated the safety and efficacy of fermented oyster extract (FGO) supplementation in children aged 6 to 9 yrs with heights between the third and 25th percentiles for age and gender.
SUBJECTS/METHODS: In this randomized, double-blind, placebo-controlled trial, subjects received FGO (n = 40) or placebo (n = 40) once daily (500 mg/day) for 24 weeks. This study evaluated the height growth, bone age (BA), growth hormone (GH), insulin-like growth factor 1 (IGF-1), insulin-like growth factor binding protein 3 (IGFBP-3), and urine deoxypyridinoline (DPD) for the efficacy of FGO and sex hormones, including estradiol, luteinizing hormone, and testosterone, for its safety. Finally, 66 children (33 each in the FGO and placebo group) completed the study. No significant baseline differences existed between the 2 groups.
RESULTS: After 24 weeks, the FGO group showed significant improvements in height, height SD score, and height velocity (all P < 0.001). BA and BA delay improved significantly in the FGO group ( P = 0.024 and P = 0.035). The FGO group showed significantly greater changes in the IGF-1 and urine DPD levels ( P = 0.010 and 0.001, respectively). The GH and IGFBP-3 concentrations increased in the FGO group, but the difference between the two groups was not significant. No serious adverse events or increase in sex hormones were observed after FGO supplementation, assuring its safety.
CONCLUSION: FGO may be a safe and effective health supplement ingredient for height growth in children, irrespective of gender. Future studies will need to evaluate the long-term effects of FGO and its applicability across various populations.
상세정보 수정요청해당 페이지 내 제목·저자·목차·페이지SUBJECTS/METHODS: In this randomized, double-blind, placebo-controlled trial, subjects received FGO (n = 40) or placebo (n = 40) once daily (500 mg/day) for 24 weeks. This study evaluated the height growth, bone age (BA), growth hormone (GH), insulin-like growth factor 1 (IGF-1), insulin-like growth factor binding protein 3 (IGFBP-3), and urine deoxypyridinoline (DPD) for the efficacy of FGO and sex hormones, including estradiol, luteinizing hormone, and testosterone, for its safety. Finally, 66 children (33 each in the FGO and placebo group) completed the study. No significant baseline differences existed between the 2 groups.
RESULTS: After 24 weeks, the FGO group showed significant improvements in height, height SD score, and height velocity (all P < 0.001). BA and BA delay improved significantly in the FGO group ( P = 0.024 and P = 0.035). The FGO group showed significantly greater changes in the IGF-1 and urine DPD levels ( P = 0.010 and 0.001, respectively). The GH and IGFBP-3 concentrations increased in the FGO group, but the difference between the two groups was not significant. No serious adverse events or increase in sex hormones were observed after FGO supplementation, assuring its safety.
CONCLUSION: FGO may be a safe and effective health supplement ingredient for height growth in children, irrespective of gender. Future studies will need to evaluate the long-term effects of FGO and its applicability across various populations.
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목차
- ABSTRACT
- INTRODUCTION
- SUBJECTS AND METHODS
- RESULTS
- DISCUSSION
- REFERENCES
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