인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2026.6
- 수록면
- 504 - 520 (17page)
이용수
초록· 키워드
BACKGROUND/OBJECTIVES: Maintaining muscular power is essential for preventing sarcopenia and ensuring optimal physical performance. Although inadequate vitamin D levels and environmental pollutants are increasingly recognized as threats to musculoskeletal integrity, their synergistic impact has not been fully established. This study examined how the vitamin D status and atmospheric contaminants independently and collectively influence the prevalence of suspected sarcopenia, defined strictly as low handgrip strength.
SUBJECTS/METHODS: This cross-sectional analysis included 20,304 individuals from the Health Examinees cohort using baseline data. Vitamin D insufficiency was categorized as circulating 25-hydroxyvitamin D [25(OH)D] concentrations below 20 ng/mL. Residential address-linked data were used to estimate the annual mean exposure to nitrogen dioxide (NO₂) and particulate matter (PM<sub>2.5</sub> and PM<sub>10</sub>). Possible sarcopenia was distinguished from clinically diagnosed sarcopenia by relying solely on gender-specific low grip strength cut-offs, according to the Asian Working Group for Sarcopenia guidelines. Multivariable linear and logistic regression models were used to assess the associations, and the interaction terms were included to evaluate the effect modification according to the vitamin D status.
RESULTS: Suboptimal vitamin D levels were widespread in the cohort (65.0%) and strongly correlated with increased pollutant exposure. After accounting for all potential confounders, elevated PM<sub>2.5</sub>, PM<sub>10</sub>, and NO₂ levels were associated with reduced serum 25(OH)D levels and a greater likelihood of suspected sarcopenia. Significant interplay was detected between PM<sub>2.5</sub> exposure and the vitamin D status, suggesting a combined effect on muscle health ( P for interaction = 0.005).
CONCLUSION: Vitamin D deficiency and air pollution exposure are independently associated with possible sarcopenia. In particular, PM<sub>2.5</sub> and a vitamin D deficiency exhibit a synergistic adverse association. These findings suggest that adequate vitamin D levels may be protective against pollution-associated declines in muscle strength, highlighting the need for longitudinal studies to explore integrated nutritional and environmental prevention strategies.
상세정보 수정요청해당 페이지 내 제목·저자·목차·페이지SUBJECTS/METHODS: This cross-sectional analysis included 20,304 individuals from the Health Examinees cohort using baseline data. Vitamin D insufficiency was categorized as circulating 25-hydroxyvitamin D [25(OH)D] concentrations below 20 ng/mL. Residential address-linked data were used to estimate the annual mean exposure to nitrogen dioxide (NO₂) and particulate matter (PM<sub>2.5</sub> and PM<sub>10</sub>). Possible sarcopenia was distinguished from clinically diagnosed sarcopenia by relying solely on gender-specific low grip strength cut-offs, according to the Asian Working Group for Sarcopenia guidelines. Multivariable linear and logistic regression models were used to assess the associations, and the interaction terms were included to evaluate the effect modification according to the vitamin D status.
RESULTS: Suboptimal vitamin D levels were widespread in the cohort (65.0%) and strongly correlated with increased pollutant exposure. After accounting for all potential confounders, elevated PM<sub>2.5</sub>, PM<sub>10</sub>, and NO₂ levels were associated with reduced serum 25(OH)D levels and a greater likelihood of suspected sarcopenia. Significant interplay was detected between PM<sub>2.5</sub> exposure and the vitamin D status, suggesting a combined effect on muscle health ( P for interaction = 0.005).
CONCLUSION: Vitamin D deficiency and air pollution exposure are independently associated with possible sarcopenia. In particular, PM<sub>2.5</sub> and a vitamin D deficiency exhibit a synergistic adverse association. These findings suggest that adequate vitamin D levels may be protective against pollution-associated declines in muscle strength, highlighting the need for longitudinal studies to explore integrated nutritional and environmental prevention strategies.
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목차
- ABSTRACT
- INTRODUCTION
- SUBJECTS AND METHODS
- RESULTS
- DISCUSSION
- REFERENCES
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