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EDP Sciences BIO Web of Conferences 59
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    초록·키워드

    The first section of this paper reviews the research on the development of avascular tumours, which are tumours without a blood artery network to supply their cells with nutrients. The process of avascular tumours is then illustrated utilising classical PDE model, which is composed of an outer layer of actively dividing cells and an inner core of dead cells (referred to as necrotic cells) (called proliferating cells). The model takes into account both necrosis (a type of cell death brought on by changes in the cell’s microenvironment) and apoptosis (a sort of programmed cell death that takes place when a cell reaches the end of its normal lifespan). We offer a modified, simplified model and study how the relative importance of these mechanisms shifts as the tumour enlarges using a mix of numerical and analytical methods.

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