인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Background There were increased claims of thrombotic events in ICU-bound patients with COVID-19. We designed this observational study to examine implementation of systemic anti-coagulation on arterial catheter failure (ACF) and to identify contributing risk factors.Methods A total of 245 COVID-19 subjects were included in this observational study, 48 patients in the non-systemic, (Non-SA), anticoagulation cohort, and 197 patients in the systemic (SA), anticoagulation group. The first arterial line inserted on ICU admission for every patient was monitored regarding its duration of patency, number and location of consecutive arterial lines inserted during stay in ICU. Demographics of patients, ICU parameters and risk factors for ACF were analyzed.Results The percentage of ACF was significantly higher in Non-SA group, 45.8 % when compared to SA group, 25.9%, P = 0.007. The patients with ACF exhibited higher D-dimer, co-morbidities, diabetic patients, received aspirin and mortality than the patent group, respectively, p = 0.002, p = 0.002, p < 0.0001, p < 0.0001, and p < 0.0001. This group also received higher sedation and vasopressors consumption and more prone position on mechanical ventilation, respectively, p < 0.0001, p < 0.0001, and p < 0.0001 when compared to patent group. They had prolonged length of stay in ICU and hospital, respectively, p = 0.001 and p = 0.042. The cumulative incidence of index ACF was (Log-rank test 6.95, P = 0.008) when comparing SA group versus non-SA group, respectively, P = 0.007. On Cox-proportional hazard multivariate regression analysis, independent predictors of ACF were: platelets level (per 100.000 increase), (HR 1.40; 95% CI 1.12–1.74; p = 0.003), blind technique versus ultrasound in arterial line insertion (HR 4.12; 95% CI 1.60–10.67; p = 0.003), and prone position in ICU (HR 2.07; 95% CI 1.180–3.63; p = 0.011).Conclusion We observed three independent predictors of arterial line failure including platelets level and ultrasound use during arterial catheter insertion and prone position in ICU. Systemic anticoagulation was associated with more patency of arterial catheter than prophylactic therapy group.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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