인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Abstract Background Diabetic retinopathy (DR) is a chronic progressive, ocular disease affecting the retinal microvasculature accompanied by hyperglycaemia and different situations related to diabetes mellitus (DM) such as hypertension (HTN). Till now, the majority of researches demonstrated an insignificant correlation between lipid profile parameters and DR. Novel serum lipid markers (apolipoproteins) which are the protein portion of lipoproteins were recently linked to DR, and observed that the increased apo B and high apo B/apo A ratio accompanied by a higher possibility of proliferative DR. Aim To assess the relation between novel serum lipid markers and various grades of DR in a sample of type 2 Egyptian diabetic cases. Methods This study comprised 80 cases with type 2 diabetes mellitus (T2DM) divided into 3 groups: T2DM cases with proliferative diabetic retinopathy (PDR) (group I), T2DM cases with non-PDR (group II) and T2DM cases without DR as a control group (group III). Fasting plasma glucose (FPG), 2-h postprandial plasma glucose (2hpp), haemoglobinA1c (HbA1c), cholesterol (chol), triglycerides (TG), LDL, HDL and serum apolipoprotein A and B level. Complete medical history was taken from entire cases with a special focus on the duration of HTN and diabetes and full clinical examination (including BP and BMI). Results There was a significant difference regarding serum apo B, apo B/apo A ratio, TG, total chol, LDL ( p <0.001*), DM duration ( p =0.002), HTN duration ( p =0.014), SBP ( p =0.006), DBP ( p =0.013), BMI ( p =0.050) and HbA1c ( p =0.025), being higher in group I than group II than group III; also, there was a significant difference between them with regard to serum apo A ( p =0.010), and HDL ( p =0.047) being higher in group III than group II than group I. On comparing group I with group II using Post hock Tukey’s test there was a significant difference regarding serum apo B ( p =.023) and apo B/apo A ratio ( p =.002). There was a statistically significant positive correlation between serum apo B/apo A ratio and diabetic duration ( r =0.248), HTN d ( r =0.4), HbA1c ( r =.47), LDL ( r =0.68), triglycerides ( r =0.52), cholesterol ( r =0.70) and a statistically significant negative correlation between serum apo B/apo A ratio and HDL ( r =0.37) in all subjects. In addition, HTN duration was demonstrated to be the most independent factor affecting B/A ratio. Conclusion Serum apo B and serum apo B/apo A ratio in diabetic cases are higher in the presence of retinopathy, triglycerides, total cholesterol, LDL, and HDL, and it is also higher in proliferative than non-proliferative diabetic retinopathy. The current study emphasizes on the potential correlation between the high serum apo B, serum apo B/apo A ratio and the advancement of DR.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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