인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Abstract Objectives Active pharmaceutical ingredients for paediatric patients are formulated at hospital pharmacy services and compounding pharmacies when they are not commercially available. This work evaluated the quality and stability of lozenges, an orodispersible dosage form, elaborated by a simple and low-cost moulding process. Methods The lozenges were formulated with 10 mg of hydrochlorothiazide as an active pharmaceutical ingredient and a commercial excipient suitable for paediatric use (Natatroche ® ). A High-Performance Liquid Chromatography system was used to quantify the active pharmaceutical ingredient from pure and extracted from dosage form samples. The quality of the lozenges was checked by the European Pharmacopeia tests indicated for oromucosal preparations, and additional quality tests specified for orodispersible and dispersible tablets. The stability of this dosage form was evaluated by the International Conference of Harmonization indications. Results The chromatographic method could quantify the active pharmaceutical ingredient extracted from excipient matrix. This formulation met uniformity of dosage units test for oromucosal dosage forms and, in addition, met the disintegration time test for orodispersible tablets and the fineness of dispersion test for dispersible tablets. Hydrochlorothiazide in lozenges was stable for 60 days when stored at 5 °C. Conclusions Moulded hydrochlorothiazide tablets are quick-to-prepare dosage forms that can be prepared in a simple, low-cost manufacturing process. They are safe and stable, disintegrate quickly in the mouth, and are therefore a recommended option for children, or other patients with swallowing problems.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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