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Elsevier BV Journal of Biological Chemistry 300(3)
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    초록·키워드

    Huntington's disease is an autosomal dominant condition caused by expanded repeats of the CAG sequence on chromosome 4 in which the nerve cells in the basal ganglia progressively break down. Depending on the number of repeats past the disease-causing threshold, the disease severity varies among individuals. Those who have longer CAG repeats tend to have an earlier onset of the disease and a more severe form of the disease. Melamine is a chemical compound which has previously been used in cell studies for gene assessment and detection and has potential for use in the human body, (with consideration of gene-toxicity).

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