인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
The cell wall is a foundational structure in many bacterial cells, functioning to give the cell its shape and mediate the stress from the pressure of turgor. In gram-positive bacteria, such as Bacillus subtilis, the cell wall is decorated with cross-linked peptidoglycan, proteins, and anionic polymers known as teichoic and teichuronic acids. In B. subtilis, it is known that teichoic acids abundantly decorate the cell wall, whereas teichuronic acids are only present in phosphate-limiting conditions. Overall, these anionic polymers have functions that are important for cell function. Firstly, they provide an overall negative charge to the cell wall, allowing them to act as a reservoir for cations. They've also been shown to regulate autolysin activity, scaffold cell-surface proteins, and serve as receptors for the binding of phages. In this project, we hypothesize that teichuronic acid has a potential novel role in biofilm formation and development. To study this, we created a knock-out of the operon responsible for the biosynthesis of teichuronic acid, that which we observed that there's a delay in biofilm formation and an earlier biofilm disassembly compared to the wild-type. We also observed that eliminating teichuronic acid led to an impaired efficacy of bacteria colonizing the root of plants and a significantly lesser sporulation efficiency. Finally, we observe that teichuronic acid is involved in the regulation of pulcherrimin production in B. subtilis, which is a biofilm-associated pigment. Based on our preliminary results, we propose a potential novel function of teichuronic acid, an under-characterized anionic polymer, in biofilm formation and development and the regulation of pulcherrimin in B. subtilis. This project was provided substantial support by the Office of Undergraduate Research and Fellowships (URF) at Northeastern University.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
최근 본 자료 전체보기
