인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Breast cancer is a heterogenous disease and is divided into subtypes based on hormone receptor expression. Triple Negative Breast Cancers (TNBC) lack these, and thus have limited targeted therapeutic options. TNBC is hallmarked by its aggressive nature and increased metastasis, contributing to worse patient outcomes. Many treatments for patients with TNBC carry elevated risk for recurrence and resistance, making the exploration of new therapeutic options necessary. Our lab has investigated the role of Structural Maintenance of Chromosomes 2 (SMC2), a core member of the condensin complex, in TNBC cells. SMC2 is responsible for maintaining genomic integrity, and our data has shown that in TNBC cells, SMC2 silencing increases chromosomal instability (CIN) phenotypes, decreases cell growth, and increases cell migration. CIN is a trait of numerous cancers that advances tumor cell accumulation of genetic defects. We hypothesize that SMC2 loss will not induce the same effects in normalized mammary epithelial cells as displayed in TNBC cells. To begin to test this hypothesis, SMC2 was silenced in normalized mammary epithelial cells. We identified that SMC2 loss prompts an increase in CIN phenotypes including multinucleation and dysmorphic nucleation, as well as an increase in cell migration and a reduction in cell growth, indicating that the effects are similar to TNBC cells. Future studies will explore the effects of silencing SMC2 in a variety of different cell types.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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