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Springer Science and Business Media LLC Stem Cell Research & Therapy 15(1)
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    초록·키워드

    MSCs expanded with different batches of media have higher levels of heterogeneity from the perspective of cell subpopulation composition at transcriptome levels and therapeutic inconsistency. The CD317<sup>+</sup> subpopulation has enhanced immune suppression activities. And the percentage of CD317<sup>+</sup> MSCs within MSCs is tightly correlated with its immune suppression activities, and also contributes to the heterogeneity and therapeutic inconsistency of MSCs. the CD317<sup>+</sup> MSCs have increased expression levels of PTX3, which might stabilize the TSG6 protein and improve the therapeutic effects CONCLUSIONS: Thus, purifying CD317<sup>+</sup> MSCs is one efficient strategy to reduce MSC heterogeneity and increase the therapeutic consistency of MSCs.

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