인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
ObjectiveThis study examines to what extent vein wall thickness, collagen arrangements, muscular layers distribution, immunohistochemical presentation of endothelial cell arrangement, and adventitia layers placement differed in patients with small painful veins versus large painful symptomatic varicose veins (VVs).Methods and MaterialsThis study was conducted from June 2022 to September 2022 at Valley Vein Health Center (VVHC), a rural phlebology outpatient clinic. Ten samples from each of the three subjects were collected (n=30), five were small symptomatic veins, and five were large symptomatic veins. All tissue blocks were cut transversely, perpendicular to the vessel axis, into 5-micrometer-thick sections. Three stains were chosen: Masson trichrome, hematoxylin and eosin, and a cluster of differentiation 31 (CD31). Statistical analysis was done with the GraphPad statistical program. Comparisons between vein wall thickness were made using Student’s t-test.ResultsThe average thickness of small veins was less than large veins (426μm+26.1μm versus 480μm+19.2μm, respectively), p<0.001. Histologic and immunohistochemical (CD31) analysis of small symptomatic VVs by H&E and trichrome stain showed an endothelial layer overlying the media, mostly of elastic tissue fibers, and smooth muscle bundles. CD31 expression analysis demonstrated more endothelial channels in the tunica media of the enlarged veins compared to smaller vessels. The larger vein's microscopic structure was variable with irregular collagen arrangement, clumped elastin layer appearance, feathered muscular layer distribution, and thickened adventitia layer placement.ConclusionThe morphological distinctions in VVs highlighted in this study need to be considered to develop potential drug therapies tailored to women.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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