인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Theranostic systems enable early cancer diagnostic and treatment. In this work, we prepared Na-caseinate coated magnetic nanoparticles (MNP) to assess their capability as a theranostic system. This system enables monitoring by magnetic particle imaging (MPI), drug delivery and magnetic hyperthermia. MNP were synthesized in a continuous flow, coated with Na-caseinate and enzymatically crosslinked with transglutaminase to increase their colloidal stability and enable drug loading. They were investigated concerning their magnetic behaviour by DC magnetization measurements (DCM), magnetic particle spectroscopy (MPS) and AC-magnetometry to evaluate their suitability for MPI and hyperthermia. Further, their stability in different salt solutions as well as their encapsulation efficiency with a hydrophobic model drug (nile red), cell viability and uptake were investigated. Our results show that the Na-caseinate coating of MNP marginally effects the magnetic behaviour of the MNP with a consistent magnetization saturation <i>M</i> <sub>S</sub> of 109(5) A m<sup>2</sup> per kg(Fe) for uncoated and casein coated MNP and with a decrease of <15% of <i>A</i> <sub>3</sub>*, but only a slight decrease of 2% of <i>A</i> <sub>5</sub>/<i>A</i> <sub>3</sub> for Na-caseinate coated MNP. Furthermore, the Na-caseinate coating of MNP increased their salt stability, under unchanged magnetic behaviour. Drug loading (up to ∼75%) and release kinetics such as the delivery into cutaneous squamous cell carcinoma cells (SCL-1) was shown. Our results demonstrate that casein coated MNP are highly promising candidates for theranostic applications in drug delivery, magnetic hyperthermia and magnetic particle imaging.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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