인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
The regulation of glial cell activation is a critical step for the treatment or prevention of neuroinflammation-based brain diseases. However, the development of therapeutic drugs that pass the blood-brain barrier (BBB) and inhibit the glia cell activation remains a significant challenge. Herein, an ultrasmall 2D vanadium carbide quantum dots (V<sub>2</sub>C QDs) that are capable of crossing the BBB are prepared, and the admirable anti-neuroinflammatory effects are presented. The prepared 2D V<sub>2</sub>C QDs with an average size of 2.54 nm show good hydrophilicity, physiological stability, and effective BBB-crossing ability. The biological effect of V<sub>2</sub>C QDs on inflammatory reactions demonstrates fascinating results in preventing the impairment of learning and memory in BALB/c mice stimulated by lipopolysaccharide. Investigation of molecular mechanism reveals that V<sub>2</sub>C QDs not only inhibit the toll-like receptor 4/myeloid differentiation factor 88-mediated nuclear factor kappa B and mitogen-activated protein kinase pathways, but also prevent eukaryotic translation initiation factor 2α/activating transcription factor 4/C/EBP homologous protein-signaling pathway and reduce oxidative stress via activating the NF-E2-related factor-2/heme oxygenase-1-signaling pathway, leading to greatly inhibited activation of microglia and astrocytes and weakened production of inflammatory cytokines. In summary, V<sub>2</sub>C QDs exert potent anti-inflammatory effects through multiple pathways, thus offer great potential for the treatment of neurodegenerative diseases.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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