인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Gold nanoparticles, or AuNPs, have garnered significant attention in biomedical research, especially in cancer therapy, due to their unique physicochemical properties. This work discusses the bioinspired production of gold nanoparticles (AuNPs) using plant extracts as reducing and stabilizing agents. This research conducted the synthesis. Transmission electron microscopy (TEM), ultraviolet-visible spectroscopy (UV-Vis), dynamic light scattering (DLS), and Fourier transform infrared spectroscopy (FTIR) were used to analyze the synthesized nanoparticles. These approaches were used to characterize the nanoparticles’ dimensions, morphology, stability, and functional groups. At a wavelength of 532 nm, the nanoparticles, averaging 18 ± 3 nm in size, exhibited a pronounced surface plasmon resonance (SPR) peak, indicating the efficacy of the manufacturing method. Cell viability assessments performed using HeLa (a cervical cancer cell type), MCF-7 (a breast cancer cell model), and WI-38 (a healthy fibroblast cell model) demonstrated a concentration-dependent reduction in cancer cell viability, with little impact on healthy cells. At a concentration of 100 µg/mL of AuNPs, the viability of HeLa and MCF-7 cells decreased to 35.2% and 41.7%, respectively. The viability of WI-38 cells was maintained at 83.4%. The analysis of apoptosis revealed that the AuNPs induced apoptosis in cancer cells. The early and late apoptosis rates in HeLa cells were 35.4% and 45.8%, respectively, but in MCF-7 cells, they were 32.5% and 42.1%. The therapeutic efficacy of the nanoparticles was significantly enhanced by the bioactive compounds isolated from the plant. The eco-friendly synthesis method used in this study not only provides a sustainable means for nanoparticle production but also enhances the potential for their application in anti-cancer therapies. The therapeutic applications of these bioinspired AuNPs will be further explored via in vivo tests, which will be the emphasis of next research.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
최근 본 자료 전체보기
