인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Abstract Objectives Diabetic nephropathy (DN), the primary cause of end-stage renal disease, is associated with chronic hyperglycemia and elevated blood pressure. This study investigates the correlation between DN and changes in hemorheology, which involves blood flow properties. Methods At the University of Health Sciences in Istanbul, Türkiye, erythrocyte deformability, aggregation, and viscosity were measured using advanced ektacytometry (Lorrca ® Maxsis) on blood samples from 31 healthy individuals, 41 diabetic patients, and 45 patients with diabetic nephropathy from University of Health Sciences Haydarpasa Numune Training and Research Hospital. All hematocrit values were standardized to 40 %. Results Deformability of red blood cells (RBCs), indicated by the elongation index at shear stresses from 0 to 30 Pa, significantly decreased in the diabetic nephropathy group compared to diabetic patients without nephropathy and healthy controls (mean min-max SD: 0.650 (0.63–0.67) vs. 0.659 (0.64–0.68) and 0.642 (0.62–0.66), respectively; p<0.01). RBC aggregation significantly increased in the diabetic nephropathy group (mean min-max SD: 77.52 (57.84–90.7) vs. 69.96 (53.13–80.53) in controls; p<0.01), and plasma viscosity was also higher (mean min-max SD: 1.48 (1.27–2.02) mPa·s vs. 1.34 (1.22–1.72) mPa·s in controls; p<0.001). Conclusions Our findings demonstrate marked hemorheological changes in diabetic nephropathy patients. These changes suggest that evaluating RBC deformability, aggregation, and viscosity is critical for developing therapeutic strategies aimed at reducing vascular complications and preventing tissue damage in diabetics.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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