인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Abstract Background Beta-thalassemia stands as an autosomal recessive disorder that occurs as a result of a defect in the beta-globin chain synthesis of hemoglobin. Oxidative stress has a crucial role in the β -thalassemia pathophysiology. It occurs due to erythroid expansion along with ineffective erythropoiesis. The free hemoglobin oxidation generates reactive oxygen species (ROS), free heme, and iron, thus inducing membrane oxidative damage as well as vascular endothelial dysfunction. Quercetin has a crucial impact on enhancing endothelial dysfunction in thalassemia major. This work aimed to investigate endothelial dysfunction among children diagnosed as beta-thalassemia major by assessing serum level of some endothelial markers (thrombomodulin as well as human ROS) and assessing the quercetin’s therapeutic value in improving endothelial dysfunction by measuring the previous markers 12 weeks following therapy. This randomized placebo-controlled study involved 72 children developing transfusion-dependent β-thalassemia major. Their age range fell between 8 and 18 years. They were categorized into two equal groups: group I: received 12 weeks of quercetin therapy and group II: served as control group and received 12 weeks of placebo. Results Serum ferritin, C-reactive protein, and lactate dehydrogenase levels showed significantly lower values among patients after 12 weeks of quercetin therapy compared with controls. Pre-transfusion hemoglobin was significantly higher in patients after 12 weeks of quercetin therapy in comparison to controls. Frequency of transfusion was significantly less in patients after 12 weeks of quercetin therapy in comparison to controls. Serum levels of ROS and thrombomodulin showed significantly lower values among cases after 12 weeks of quercetin therapy in comparison to controls ( p < 0.001). ROS and thrombomodulin respectively carried the sensitivity of 83.33% and 77.78% and specificity of 80.56% and 83.33% in predicting the outcome with cutoff value ≤ 1073 and 232. Conclusions Twelve weeks of 500-mg quercetin therapy had a potent role in decreasing iron overload and improving frequency of transfusion, oxidative stress ,and endothelial dysfunction in children with β-thalassemia major.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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