인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Glucocorticoids play a crucial role in metabolic processes and have potent anti-inflammatory and immunosuppressive properties. Hence, developing a facile, sensitive, selective, and green approach to determine corticosteroids is essential. In this study, silver nanoparticles (Ag-NPs) were synthesized via the chemical reduction of silver nitrate using sodium borohydride in distilled water without using non-environmentally friendly organic stabilizers. The synthesized Ag-NPs exhibited high stability, as evidenced by a zeta potential measuring - 36.8 mV. Also, the average particle size was determined to be 8 ± 2 nm. These Ag-NPs were then employed as a nano fluorescence probe to establish a fluorometric assay for determining prednisolone sodium phosphate (PDN) and dexamethasone sodium phosphate (DXZ). Reduction in fluorescence intensity of Ag-NPs observed at 484 nm following excitation at 242 nm exhibited quantitative quenching upon the incremental addition of the investigated drugs, with limits of detection of 0.178 µg/mL and 0.145 µg/mL for PDN and DXZ, respectively. The quenching mechanisms were examined and explained using the Stern-Volmer and Inner Filter Effect methods. The method's selectivity was also assessed by testing other corticosteroids. The proposed method is suitable for drug testing in pharmaceutical products and quality control labs. It follows ICH guidelines and has been confirmed to be safe and eco-friendly.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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