인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Abstract Porous silicon (PS) has been widely used in biology, biomedicine, and nanotechnology. In recent years, its application in cancer therapy has received considerable attention. PS has shown low cytotoxicity, so it is reasonable to use it as an antibody conjugate for targeted anticancer drug delivery. In this work, we synthesized PS covalently attached to doxorubicin and covered by a nanometric polymer as a crosslinker between PS and the monoclonal antibody trastuzumab, using electrochemical etching for particle generation. The results revealed the formation of the antibody conjugate, obtaining particles with sizes around 250–350 nm, and a homogeneous size distribution determined by dynamic light scattering. Scanning electron microscopy (SEM) analyses showed the porous structure of the conjugate, while Fourier-transform infrared and transmission electron microscopy characterization demonstrated functionalization between PS and the antibody. The cytotoxic effect was evaluated against two breast cancer cell lines, SKBR3 (HER2+) and MCF-7 (HER2−), and one non-cancer cell line as control (HEK293). The cytotoxic effect on the SKBR3 cancer cell line was higher than on the MCF-7 and HEK293 cell lines. Notably, the targeted protein HER2 mediates the elevated cytotoxic activity exhibited by the antibody conjugate.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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