인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
<i>Chlamydia pecorum</i> is a significant cause of morbidity and mortality in koalas and a major contributor to population decline. Due to its crucial role in vaccine development and use as a strain typing tool, multiple studies have investigated the prevalence and diversity of the <i>C. pecorum</i> outer membrane protein A (MOMP), encoded by <i>omp</i>A. This prior work has shown that <i>omp</i>A genotypes vary across geographical regions, with multiple genotypes identified across Eastern Australia. Despite these earlier studies, our understanding of the diversity and distribution of MOMP remains incomplete. Here, we aimed to assess the geographical distribution, diversity, and temporal stability of the <i>C. pecorum</i> <i>omp</i>A across wild koalas infected with <i>Chlamydia</i> in north-eastern Australia. Full-length <i>omp</i>A sequences were generated from 226 samples collected from 173 unique animals from multiple koala populations over a 4-year time span. <i>C. pecorum omp</i>A genotypes F and G were the most common and were identified across all geographical regions. Genotype A was the next most common but mostly restricted to the South Brisbane region. In addition to two novel genotypes, rare genotypes, including livestock-associated types E58 and L1, and koala-associated H and I were sporadically identified. Comparison with historical <i>omp</i>A genotypes showed that the distribution of genotypes has remained stable over the past decade, suggesting limited selective pressure despite ongoing vaccination trials and management programmes. The stability of genotypes coupled with the identification of novel and livestock-associated genotypes underscores the importance of continued surveillance to inform future vaccine development and conservation strategies for koalas.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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