인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Abstract Background Fluorodeoxyglucose positron emission tomography combined with computed tomography (FDG-PET/CT) is a key tool in the diagnosis, staging, and restaging of tumors. Currently, liver Standardized Uptake Value (SUV) has been adopted as a background tissue in a number of publications and guidelines, including the Positron Emission Tomography Response Criteria in Solid Tumors (PERCIST criteria). Recently, hepatic steatosis has become the most prevalent chronic liver disease, often progressing to cirrhosis, with obesity and its related complications on the rise. Therefore, the current study aimed to assess the relationship between non-alcoholic fatty liver disease (NAFLD), obesity, and FDG uptake, as well as to evaluate the reliability of SUV measurements normalized to body weight versus those normalized to lean body mass, in relation to body mass index (BMI). Patients and methods Fifty cases were included in this study, which were first categorized into non-alcoholic fatty liver disease (NAFLD) with a mean liver Hounsfield Units (HU) of 33.5 ± 8.65 SD and non-fatty liver groups with a mean liver HU of 59.5 ± 8.81 SD. The cases were then further categorized according to body mass index into three groups: normal (18.5–24.9 kg/m 2 ), overweight (25–29.9 kg/m 2 ), and obese (≥ 30 kg/m 2 ). Standardized-uptake value (SUV) mean (SUV mean) and maximum (SUV max), SUV normalized to lean body mass (LBM) mean (SUL mean), and SUL maximum were measured. Results The measured SUV max and SUV mean normalized to body weight (BW) showed no significant difference between the NAFLD and non-fatty liver groups, with p -values of 0.666 and 0.122, respectively. Spleen attenuation showed a statistically significant difference ( p = 0.027), with the obese group having a lower mean spleen attenuation compared to the normal weight and overweight groups. Both SUV BW values demonstrated highly significant differences across BMI categories, with an increasing slope from the normal weight group to the obese group, where the p -value for SUV max was 0.016 and for SUV mean was 0.027. In contrast, SUL values showed no significant differences, with p -values of 0.313 and 0.550 for SUL max and SUL mean, respectively. Conclusion There was no association between hepatic fatty infiltration and FDG uptake in terms of SUV BW . On the basis of these data, it is acceptable to use the liver as a comparator for extrahepatic foci of increased FDG activity in patients with fatty liver disease. However, it is more reliable to use SUL values in obese patients.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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