인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Abstract Cardiac patches, typically made from non‐conductive polymers, are a promising treatment for myocardial infarction (MI). Introducing electroconductive fibres in these patches improves clinical outcomes, but current production methods are limited. This study aims to design and manufacture electroconductive polymeric cardiac scaffolds that closely match native tissue, using pressurised gyration (PG) and conductive polymers (CP). In this study, for the first time, fibres from polypyrrole (PPy) with polycaprolactone (PCL) in chloroform and Poly(3,4‐ethylenedioxythiophene)‐poly(styrenesulfonate) (PEDOT:PSS) with polyethylene oxide (PEO) in water, are pressure spun with varying CP concentrations (5–10% w/v) and applied pressures (0–0.2 MPa). SEM shows fibres resemble the thickness and uniformity of natural cardiac fibres, as PEDOT:PSS 5%, 0 MPa matched endomysium, PEDOT:PSS 10%, 0 MPa aligned with perimysium, and PPy 7.5%, 0 MPa mimicked epimysium fibres, with diameters of 0.38, 1.02, and 3.88 µm, respectively. Four‐point probe testing reveals the closest electrical conductivity measurement to the reported cardiac chambers values is 0.22 S m −1 , achieved by PPy 10%, 0.2MPa. FTIR verified the absence of residual solvent, confirming conductivity is due to polymer bonds. The study confirms the produced fibres have ideal electroconductive and physicochemical properties for cardiac tissue engineering, demonstrating PG's potential as a scalable technique for electroconductive fibres manufacturing, advancing cardiac patch development and MI treatment.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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