인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Abstract Objectives The study aimed to explore the potential mechanism of Kushen Herpes Tincture in treating herpes zoster in aging people based on network pharmacology. Methods Four herbs in Kushen Herpes Tincture were screened for transdermal active ingredients by TCMSP and HERB databases. Topological Polar Surface Area (TPSA) smaller than 60 Å square (Å 2 ) was used to screen the good at cell membrane-penetrating compounds. Potential targets of compounds were gathered from TCMSP, HERB, and SwissTargetPrediction. GeneCards and DisGeNET databases were used to screen herpes zoster-related targets. The targets were analyzed for protein interactions and KEGG enrichment. Among the top 20 targets, STAT3 and EGFR were subjected to cell experiment validation. Results Kushen Herpes Tincture was predicted to act on 51 herpes zoster-related targets. These targets were retraced to 103 cell membrane-penetrating compounds. Protein interactions proposed STAT3 and EGFR as two among the top 10 targets. The key KEGG pathway contained C-type lectin receptor signaling pathway, PI3K-Akt signaling pathway, etc. STAT3 and EGFR were upregulated in human keratinocyte and human epithelial cells after varicella-zoster virus infection, while decreased by Kushen Herpes Tincture treatment. Kushen Herpes Tincture restricted varicella-zoster virus replication in vitro . Conclusions Kushen Herpes Tincture may exert its therapeutic effect on aging herpes zoster through multi-component action on multi-targets and multi-pathways, including STAT3 and EGFR.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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