인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Abstract Background Psoriatic arthritis (PsA) is associated with increased cardiovascular risk. The role of serum uric acid (SUA) in endothelial dysfunction in PsA remains unclear. This work aimed to investigate the relationship between SUA levels, endothelial dysfunction, and disease activity in PsA patients. Patients and methods This case–control study included 50 PsA patients and 50 matched healthy controls. Carotid intima-media thickness (CIMT), lipid profiles, inflammatory markers, and SUA levels were assessed. Disease activity was evaluated using the disease activity assessment in psoriatic arthritis (DAPSA), the Psoriasis Area and Severity Index, and functional assessment was done using the Modified Health Assessment Questionnaire scores. Results PsA patients had significantly higher CIMT, SUA levels, and atherogenic lipid profiles compared to controls ( p < 0.001). Hyperuricemic PsA patients had increased CIMT and worse lipid profiles than normouricemic patients ( p < 0.001). There was a statistically significant difference in ejection fraction between the two subgroups of PsA patients as it was decreased in hyperuricemic patients. SUA levels were positively correlated with CIMT ( r = 0.734, p < 0.001), DAPSA score ( r = 0.371, p = 0.008), and total cholesterol/high-density lipoprotein risk ratio ( r = 0.312, p = 0.027). CIMT was also correlated positively with disease activity measures and lipid profile components. Multivariate analysis identified total cholesterol as the sole independent predictor of CIMT in PsA patients ( p < 0.001). Conclusion Hyperuricemia in PsA patients may represent the missing link between endothelial dysfunction, chronic inflammation, and disease activity. It could contribute to accelerated atherosclerosis in PsA patients, highlighting the importance of closely monitoring serum uric acid levels, lipid profiles, and carotid intima-media thickness alongside disease activity scores as part of their management plan.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
최근 본 자료 전체보기
