인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
The cytoskeleton comprises polymers from protein filaments shaped in an organized structure. This structure contributes significantly to the cell's function and viability. Decades of research have implicated that the cytoskeleton's dynamic nature is associated with downstream signaling events that further regulate cellular activity and control aging and neurodegeneration. This study aims to investigate the transcriptional changes of the cytoskeletal genes and their regulators in five age-related diseases: Hypertrophic Cardiomyopathy (HCM), Coronary Artery Disease (CAD), Alzheimer's disease (AD), Idiopathic Dilated Cardiomyopathy (IDCM), and Type 2 Diabetes Mellitus (T2DM). An integrative approach of machine learning-based models and differential expression analysis was employed to identify potential biomarkers based on the cytoskeletal genes. Multiple machine-learning algorithms were used, where the Support Vector machines (SVM) classifier achieved the highest accuracy. The study highlighted 17 genes involved in the cytoskeleton's structure and regulation associated with age-related diseases. The results provide a holistic overview of the role of transcriptionally dysregulated cytoskeletal genes in age-related diseases. This study pinpoints cytoskeletal genes and regulators of the cytoskeleton that can be utilized as potential markers and drug targets.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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